Chang R C, Chung K H, Kao S Y
Dental Department, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Proc Natl Sci Counc Repub China B. 1991 Oct;15(4):212-9.
Bony defects measuring 12x12x12 millimeters in size were created bilaterally over the proximal end of the femurs of 10 Macaca cyclopis monkeys and implanted with particulate hydroxylapatite. The animals were sacrificed according to a predetermined sequence of post-operative 1, 2, 3, 6, and 8 months. The specimens taken from the implant sites in the two femurs of each animal were chosen randomly either for histological observation or for compressive strength tests under vertical loads. Histological pictures showed only loose fibrous tissue over the interparticular space of the implant site at the first month after surgery. Woven bone could be observed over the basal part of the implant site at the second month. New bone formed over the central part of the implant site at the third month after surgery. Continuing maturation of the bone tissue could be observed over the interparticular space of the implant site until the late stages at the 6th and 8th month after surgery. The results of compressive strength tests were compatible with the histological observations. The value of the elastic modulus was low initially at the first month, but increased gradually with time due to organization of fibrous tissue, condensation of HA particles, and ossification as well as maturation of bone tissue. The value of elastic modulus at the third month was equal to that of cortical bone tissue and even two-fold higher than that of the cortical bone at the eighth month after surgery. These results provide valuable information about the compressive strength of the HA implant in host tissue.
在10只食蟹猕猴的股骨近端两侧制造了尺寸为12×12×12毫米的骨缺损，并植入了颗粒状羟基磷灰石。按照术后1、2、3、6和8个月的预定顺序对动物实施安乐死。从每只动物的两侧股骨植入部位采集的标本，随机选择用于组织学观察或垂直载荷下的抗压强度测试。组织学图片显示，术后第一个月，植入部位颗粒间隙上仅见疏松纤维组织。术后第二个月，在植入部位基部可见编织骨。术后第三个月，植入部位中央部分形成新骨。直至术后第6个月和第8个月的后期阶段，均可观察到植入部位颗粒间隙处骨组织持续成熟。抗压强度测试结果与组织学观察结果相符。弹性模量值在第一个月时最初较低，但随着时间的推移，由于纤维组织的机化、羟基磷灰石颗粒的凝聚、骨化以及骨组织的成熟而逐渐增加。术后第三个月的弹性模量值与皮质骨组织相等，甚至在术后第八个月时比皮质骨高出两倍。这些结果为羟基磷灰石植入物在宿主组织中的抗压强度提供了有价值的信息。
