Wong M Y, Hong C Y, Chang W K
Taiwan Yi Xue Hui Za Zhi. 1989 Feb;88(2):152-8.
The biological response to the resorbable and nonresorbable bone grafting materials implanted in the surgically created defects was compared in 4 Maccaca cyclopsis. Intraosseous angular defects were created on the mesial side of both upper canines and premolars by an air driven fissure bur. The root surface was planed, then hydroxylapatite (HA) and tricalcium phosphate (TCP) were inserted into the right side defects respectively. The left side canine received no implants and served as the control site. The animals were sacrificed 6 and 16 weeks after the experiment. Histologically, the two implant materials were well tolerated by the surrounding tissues and did not elicit any adverse inflammatory reaction. During the 16 weeks periods, TCP was biodegraded through phagocytosis by histiocytes and multinucleated giant cells. The residual particles were incorporated into the new bone matrix and displayed the bone growth guiding property. HA particles were dense and larger in size with low resorption rate, therefore, encapsulation by fibrous tissue was more commonly seen. Although direct bone deposition adjacent to the HA particle surface was apparently found, new bone formation was observed only at the apical portion adjacent to the host alveolar bone. These findings suggested that HA might rather play the role as a biocompatible filler. However, HA was more effective in blocking the downgrowth of the junctional epithelium. Nevertheless, these two implant materials could not hasten the healing process, because new bone formation was observed to be more distinct in the control site.
在4只菲律宾眼镜猴中比较了植入手术造成的缺损处的可吸收和不可吸收骨移植材料的生物学反应。用气驱动裂钻在上颌两侧尖牙和前磨牙的近中侧制造骨内角形缺损。将牙根表面刨平，然后分别将羟基磷灰石（HA）和磷酸三钙（TCP）植入右侧缺损处。左侧尖牙不植入任何材料作为对照部位。在实验6周和16周后处死动物。组织学观察显示，两种植入材料均能被周围组织良好耐受，未引发任何不良炎症反应。在16周的观察期内，TCP通过组织细胞和多核巨细胞的吞噬作用发生生物降解。残留颗粒被整合到新的骨基质中，并表现出骨生长引导特性。HA颗粒致密且尺寸较大，吸收率低，因此，更常见的是被纤维组织包裹。虽然在HA颗粒表面明显发现有直接的骨沉积，但仅在靠近宿主牙槽骨的根尖部分观察到新骨形成。这些发现表明，HA可能更像是起到生物相容性填充物的作用。然而，HA在阻止结合上皮向下生长方面更有效。尽管如此，这两种植入材料都不能加速愈合过程，因为在对照部位观察到新骨形成更为明显。
