原发性耐药是耐药结核病的主要原因。
[Primary drug-resistance is the main cause of drug-resistant tuberculosis].
作者信息
Mei Jian, Xue Zhen, Shen Xin, Shen Guo-miao, Gui Xiao-hong, Shen Mei, Gao Qian
机构信息
Department of Tuberculosis Disease Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 2006 Feb;29(2):75-8.
OBJECTIVE
To investigate the main cause of drug-resistant tuberculosis.
METHODS
Clinic isolates of Mycobacterium tuberculosis from 1996 to 2004 in Shanghai were analyzed and the proportion of isolates from new cases (the proxy of primary drug-resistance) and retreatment cases (the proxy of acquired drug-resistance) were calculated. Mycobacterial interspersed repetitive units (MIRU) genotyping was performed and analyzed on pairs of isolates of Mycobacterium tuberculosis from 16 recurrent patients with drug-resistant tuberculosis.
RESULTS
Of all 8 120 isolates of Mycobacterium tuberculosis from new cases, 707 isolates (8.7%) were drug resistant. Of all 610 isolates from retreatment cases, 150 isolates (24.6%) were drug resistant. Primary drug resistance accounted for 82.5% (707/857) of all drug resistant isolates. Based on the MIRU genotypes, 13 of all 16 recurrent drug-resistant patients were reinfected with new drug-resistant strain of Mycobacterium tuberculosis.
CONCLUSION
Primary drug-resistance is the main cause of drug-resistant tuberculosis.
目的
探讨耐多药结核病的主要病因。
方法
分析1996年至2004年上海临床分离的结核分枝杆菌，计算新发病例（代表原发性耐药）和复治病例（代表获得性耐药）分离株的比例。对16例复发性耐多药结核病患者的结核分枝杆菌分离株进行分枝杆菌间隔重复单位（MIRU）基因分型并分析。
结果
在8120例新发病例的结核分枝杆菌分离株中，707株（8.7%）耐药。在610例复治病例的分离株中，150株（24.6%）耐药。原发性耐药占所有耐药分离株的82.5%（707/857）。根据MIRU基因型，16例复发性耐多药患者中有13例再次感染了新的耐多药结核分枝杆菌菌株。
结论
原发性耐药是耐多药结核病的主要病因。
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