东莨菪碱透皮贴剂去除后引发的与止吐药相关的张力障碍反应。

Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch.

作者信息

Roberge Raymond J

机构信息

Emergency Department, Magee Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA 15236, USA.

出版信息

J Emerg Med. 2006 Apr;30(3):299-302. doi: 10.1016/j.jemermed.2005.03.018.

DOI:10.1016/j.jemermed.2005.03.018

PMID:16677982

Abstract

A case of a dystonic reaction is presented that occurred after the use of prochlorperazine, metoclopramide and ondansetron for the treatment of post-operative nausea and vomiting. The onset of dystonia coincided temporally with the removal of a transdermal scopolamine patch used as adjunctive antiemetic therapy. Withdrawal of concurrently administered anticholinergic medication, after recent use of antiemetic medications with dopamine receptor (D2) inhibition, can unmask a dystonic reaction. This case also suggests that transdermal scopolamine may offer an innovative therapy for the treatment of acute dystonic reactions.

摘要

本文报告一例肌张力障碍反应病例，该反应发生在使用丙氯拉嗪、甲氧氯普胺和昂丹司琼治疗术后恶心和呕吐之后。肌张力障碍的发作在时间上与作为辅助性止吐疗法使用的透皮东莨菪碱贴片的移除同时发生。在近期使用具有多巴胺受体（D2）抑制作用的止吐药物后，停用同时给予的抗胆碱能药物可能会引发肌张力障碍反应。该病例还表明，透皮东莨菪碱可能为急性肌张力障碍反应的治疗提供一种创新疗法。