一名儿科患者因多潘立酮导致的急性肌张力障碍
Acute Dystonia Secondary to Domperidone in a Pediatric Patient.
作者信息
Shahbaz Amir, Elahi Karam, Affan Muhammad, Shahid Muhammad Faizan, Sabir Ahtesham
机构信息
Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.
Internal Medicine, Punjab Medical College, Allied Hospital, Faisalabad, PAK.
出版信息
Cureus. 2018 Nov 13;10(11):e3587. doi: 10.7759/cureus.3587.
Abstract
Domperidone is a dopamine-2 receptor (D2) antagonist. It is used as an antiemetic and has an excellent safety profile. We present a case of acute dystonia secondary to domperidone use in an 11-year-old girl. She was admitted with the diagnosis of viral gastroenteritis and received domperidone for persistent vomiting along with other supportive measures. The vomiting subsided with treatment, but she developed acute dystonia. Domperidone discontinued, and her condition improved in the next 24 hours. The patient discharged, and on a follow-up visit, she was asymptotic. A review of the literature suggests a possible association of acute dystonia with domperidone in children.
摘要
多潘立酮是一种多巴胺-2受体（D2）拮抗剂。它被用作止吐药，具有出色的安全性。我们报告一例11岁女孩因使用多潘立酮继发急性肌张力障碍的病例。她因病毒性肠胃炎入院，除其他支持性措施外，还接受了多潘立酮治疗持续性呕吐。呕吐经治疗后缓解，但她出现了急性肌张力障碍。停用多潘立酮后，她的病情在接下来的24小时内有所改善。患者出院，随访时无症状。文献综述表明，儿童急性肌张力障碍可能与多潘立酮有关。
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