核受体共激活因子的扩展领域
The expanding cosmos of nuclear receptor coactivators.
作者信息
Lonard David M, O'Malley Bert W
机构信息
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Cell. 2006 May 5;125(3):411-4. doi: 10.1016/j.cell.2006.04.021.
PMID:16678083
Abstract
About 200 coactivators play a central role in promoting gene expression mediated by nuclear receptors. This diverse group of proteins are key integrators of signals from steroid hormones and have been implicated in cancer and other diseases.
摘要
约200种共激活因子在促进由核受体介导的基因表达中起核心作用。这群多样的蛋白质是类固醇激素信号的关键整合者，并与癌症及其他疾病有关。
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