玻璃体内注射曲安奈德治疗外源性细菌性眼内炎
Intravitreal triamcinolone acetonide in the management of exogenous bacterial endophthalmitis.
作者信息
Pathengay Avinash, Shah Gaurav Yogesh, Das Taraprasad, Sharma Savitri
机构信息
Smt Kanuri-Santhamma Retina Vitreous Centre, Hyderabad Eye Research Foundation, Prof. Brien Holden Eye Research Center, L.V. Prasad Eye Institute, L.V. Prasad Marg, Banjara Hills, Hyderabad 500-034, India.
出版信息
Am J Ophthalmol. 2006 May;141(5):938-40. doi: 10.1016/j.ajo.2005.11.043.
PURPOSE
To determine the effectiveness of intravitreal triamcinolone acetonide in the management of bacterial endophthalmitis.
DESIGN
Interventional case series.
METHODS
This pilot case series included five patients (three patients after trauma and two patients after cataract surgery) with culture proven bacterial endophthalmitis. After 48 to 72 hours of the initial surgical procedure, 4 mg/0.1 ml of intravitreal triamcinolone acetonide was injected, after confirmation that the vitreous isolate was sensitive to the initially administered intravitreal antibiotics. All patients received oral ciprofloxacin 750 mg twice each day for seven days. The course of inflammation and the clinical outcome were noted.
RESULTS
In all the five cases, there was complete resolution of inflammation with favorable clinical outcome at the end of one month that was maintained at the end of three months.
CONCLUSION
Intravitreal triamcinolone acetonide could be a treatment option in the selected cases of bacterial endophthalmitis.
目的
确定玻璃体内注射曲安奈德在细菌性眼内炎治疗中的有效性。
设计
干预性病例系列。
方法
该试点病例系列包括5例经培养证实的细菌性眼内炎患者（3例外伤后患者和2例白内障手术后患者）。在初始手术48至72小时后，在确认玻璃体分离物对最初玻璃体内注射的抗生素敏感后，注射4mg/0.1ml玻璃体内曲安奈德。所有患者每天口服环丙沙星750mg，共7天。记录炎症过程和临床结果。
结果
所有5例患者炎症均完全消退，1个月时临床结果良好，并在3个月末保持。
结论
在选定的细菌性眼内炎病例中，玻璃体内注射曲安奈德可能是一种治疗选择。
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