除玻璃体内注射抗生素外，玻璃体内注射皮质类固醇用于急性眼内炎的支持和反对证据。
Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis.
作者信息
Bui Diem K, Carvounis Petros E
出版信息
Int Ophthalmol Clin. 2014 Spring;54(2):215-24. doi: 10.1097/IIO.0000000000000020.
Abstract
The use of adjunctive intravitreous corticosteroids in endophthalmitis is controversial. Preclinical models showed that early administration of corticosteroids may be important although they reported mixed results in terms of their effects on antibiotic pharmacokinetics, control of infection and prevention of retinal damage. Most published retrospective clinical studies showed no beneficial effects associated with their use. However, a single well-conducted retrospective study showed a deleterious effect. Randomized controlled trials also showed a lack of beneficial effects. At the present time, the best available evidences do not support the routine use of adjunctive intravitreous corticosteroids for treatment of acute endophthalmitis.
摘要
在眼内炎中使用辅助性玻璃体内注射皮质类固醇存在争议。临床前模型表明，早期给予皮质类固醇可能很重要，尽管它们在对抗生素药代动力学、感染控制和视网膜损伤预防方面的作用结果不一。大多数已发表的回顾性临床研究表明，使用皮质类固醇并无有益效果。然而，一项精心开展的回顾性研究显示了有害作用。随机对照试验也表明缺乏有益效果。目前，现有最佳证据不支持常规使用辅助性玻璃体内注射皮质类固醇来治疗急性眼内炎。
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