脂肪分解：CGI-58（ABHD5）的一项功能为这一谜题增添了新线索。
Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.
作者信息
Yen Chi-Liang Eric, Farese Robert V
机构信息
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
出版信息
Cell Metab. 2006 May;3(5):305-7. doi: 10.1016/j.cmet.2006.04.001.
PMID:16679288
Abstract
The hydrolysis of fat stored in adipose tissues is crucial for providing energy during fasting and exercise, and dysregulation of fat breakdown may contribute to metabolic disease. In this issue of Cell Metabolism, report that CGI-58/ABHD5, a lipid-droplet-associated protein that is mutated in a rare disease characterized by excess lipid storage, activates adipose triglyceride lipase and thus may regulate fat mobilization.
摘要
储存于脂肪组织中的脂肪水解对于在禁食和运动期间提供能量至关重要，而脂肪分解的失调可能会导致代谢性疾病。在本期《细胞代谢》中，[研究人员]报道，CGI-58/ABHD5（一种与脂滴相关的蛋白质，在一种以脂质储存过多为特征的罕见疾病中发生突变）可激活脂肪甘油三酯脂肪酶，因此可能调节脂肪动员。
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