Demeter J, Böhm U, Pálóczi K, Lehoczky D, Merétey K
First Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
J Clin Lab Immunol. 1991 Mar;34(3):141-4.
Serum immunoglobulin and natural antibody concentrations to environmental antigens have been determined in 26 hairy cell leukaemia (HCL) patients. The serum IgG, IgA and IgM levels as well as the concentration of antibodies to the majority of intestinal bacteria were found to be normal in both groups of HCL patients. In contrast to the data on the impaired humoral immunity of chronic lymphocytic leukaemia (CLL) patients, our results show that in HCL the studied aspects of humoral immunity are normal. Serum IgE levels were found to be significantly decreased in HCL when all patients were taken as a group. The difference was due to the decreased serum IgE concentration of splenectomized HCL patients, while IgE levels of untreated HCL patients did not differ statistically from that of the healthy controls.
已对26例毛细胞白血病（HCL）患者的血清免疫球蛋白和针对环境抗原的天然抗体浓度进行了测定。两组HCL患者的血清IgG、IgA和IgM水平以及针对大多数肠道细菌的抗体浓度均正常。与慢性淋巴细胞白血病（CLL）患者体液免疫受损的数据相反，我们的结果表明，HCL患者体液免疫的研究方面是正常的。将所有患者作为一个整体时，发现HCL患者的血清IgE水平显著降低。这种差异是由于脾切除的HCL患者血清IgE浓度降低，而未经治疗的HCL患者的IgE水平与健康对照组在统计学上没有差异。
