Demeter J, Mihalik R, Benczúr M, Lehoczky D, Pálóczi K
First Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Haematologia (Budap). 1991;24(2):91-9.
Peripheral blood mononuclear cell surface markers were studied in a series of 26 hairy cell leukaemia patients 19 of whom were splenectomized previously. Patients with non-symptomatic and stable disease were distinguished from those with symptomatic and/or progressive disease (also termed "active" clinical stages). In all HCL patients as a group, the absolute number of CD4+ MN cells did not differ statistically from that of the controls, while the number of CD8+ MN cells was significantly increased. The reduction of the CD4/CD8 ratio in the peripheral blood of HCL patients as compared to the controls was explained by the reduction of this ratio in patients with "active disease", while the CD4/CD8 ratio of patients with non-symptomatic and stable disease did not differ statistically from that of the controls. The CD4/CD8 ratio was found to be influenced mainly by the clinical stage of the disease, and not by the effect of splenectomy.
对26例毛细胞白血病患者的外周血单个核细胞表面标志物进行了研究，其中19例患者此前已接受脾切除术。将无症状且病情稳定的患者与有症状和/或病情进展的患者（也称为“活动期”临床阶段）区分开来。在所有毛细胞白血病患者组中，CD4+单核细胞的绝对数量与对照组相比无统计学差异，而CD8+单核细胞的数量显著增加。与对照组相比，毛细胞白血病患者外周血中CD4/CD8比值降低是由“活动期疾病”患者该比值降低所致，而无症状且病情稳定的患者的CD4/CD8比值与对照组无统计学差异。发现CD4/CD8比值主要受疾病临床阶段的影响，而非脾切除术的影响。
