Alexopoulos P, Grimmer T, Perneczky R, Domes G, Kurz A
Department of Psychiatry and Psychotherapy, Technische Universitat, Munchen, Germany.
Dement Geriatr Cogn Disord. 2006;22(1):27-34. doi: 10.1159/000093101. Epub 2006 May 4.
To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI).
A follow-up examination (average follow-up period: 3.49 +/- 2.2 years) was performed in 81 cognitively impaired, non-demented patients aged >55 years at baseline.
8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 of 8 patients with single non-memory MCI (37.5%) progressed to dementia. The clinical type of MCI is significantly associated with the likelihood of conversion to dementia.
When the clinical syndrome of MCI evolves on a neurodegenerative basis, the multiple-domain type of MCI has a less favorable prognosis than the amnestic type and may represent a more advanced prodromal stage of dementia.
研究被诊断为不同类型轻度认知障碍（MCI）患者的转归情况。
对81例基线时年龄>55岁的认知受损、非痴呆患者进行了随访检查（平均随访期：3.49±2.2年）。
32例遗忘型MCI患者中有8例（25%）、41例多领域型MCI患者中有22例（54%）、8例单一非记忆型MCI患者中有3例（37.5%）进展为痴呆。MCI的临床类型与转化为痴呆的可能性显著相关。
当MCI的临床综合征在神经退行性基础上演变时，多领域型MCI的预后比遗忘型差，可能代表痴呆更晚期的前驱阶段。
