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在家中通过非侵入性神经调节增强遗忘型轻度认知障碍的认知控制：一项随机试验。

Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial.

机构信息

Department of Neurology, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.

Neuroscape, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.

出版信息

Sci Rep. 2023 May 8;13(1):7435. doi: 10.1038/s41598-023-34582-1.

DOI:10.1038/s41598-023-34582-1
PMID:37156876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10167304/
Abstract

Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate cognitive function. In a feasibility pilot study, 30 older adults aged 60-80 years with md-aMCI were randomized to 8 sessions of transcranial alternating current stimulation (tACS) with simultaneous cognitive control training (CCT). The intervention took place within the participant's home without direct researcher assistance. Half of the participants received prefrontal theta tACS during CCT and the other half received control tACS. We observed high tolerability and adherence for at-home tACS + CCT. Within 1-week, only those who received theta tACS exhibited improved attentional abilities. Neuromodulation is feasible for in-home settings, which can be conducted by the patient, thereby enabling treatment in difficult to reach populations. TACS with CCT may facilitate cognitive control abilities in md-aMCI, but research in a larger population is needed to validate efficacy.

摘要

患有多领域遗忘型轻度认知障碍 (md-aMCI) 的个体患痴呆的风险较高，需要进行干预以保留或改善认知功能。在一项可行性试点研究中，30 名年龄在 60-80 岁之间的 md-aMCI 老年患者被随机分为接受 8 次经颅交流电刺激 (tACS) 联合认知控制训练 (CCT) 的组。干预在参与者的家中进行，没有研究人员的直接协助。一半的参与者在 CCT 期间接受前额叶θ tACS，另一半接受对照 tACS。我们观察到家庭 tACS+CCT 的耐受性和依从性都很高。在 1 周内，只有接受θ tACS 的人表现出注意力能力的改善。神经调节适用于家庭环境，可以由患者进行，从而能够为难以接触到的人群提供治疗。tACS 联合 CCT 可能有助于改善 md-aMCI 患者的认知控制能力，但需要更大规模的人群研究来验证疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/b3ad14180d75/41598_2023_34582_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/0c9e1bb9574f/41598_2023_34582_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/2673b1dd6446/41598_2023_34582_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/33431a49df94/41598_2023_34582_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/b3ad14180d75/41598_2023_34582_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/0c9e1bb9574f/41598_2023_34582_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/2673b1dd6446/41598_2023_34582_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/33431a49df94/41598_2023_34582_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/10167304/b3ad14180d75/41598_2023_34582_Fig4_HTML.jpg

相似文献

[1]
Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial.

Sci Rep. 2023-5-8

[2]
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[3]
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[4]
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[5]
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[6]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
VR-based gamma sensory stimulation: a pilot feasibility study.

Sci Rep. 2025-8-5

[2]
Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment.

Alzheimers Res Ther. 2025-7-18

[3]
Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment.

Front Psychiatry. 2025-6-2

[4]
Nonpharmacological Multimodal Interventions for Cognitive Functions in Older Adults With Mild Cognitive Impairment: Scoping Review.

JMIR Aging. 2025-5-12

[5]
Cognitive and Neuropsychiatric Effects of 40 Hz tACS Simultaneously with Cognitive Exercises for Dementia: A Randomized, Crossover, Double-Blind, Sham-Controlled Study.

Medicina (Kaunas). 2025-4-19

[6]
A Novel Real-time Phase Prediction Network in EEG Rhythm.

Neurosci Bull. 2025-3

[7]
Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders.

Biosensors (Basel). 2024-7-9

[8]
A Systematic Review of tACS Effects on Cognitive Functioning in Older Adults Across the Healthy to Dementia Spectrum.

Neuropsychol Rev. 2024-12

本文引用的文献

[1]
The economic value of targeting aging.

Nat Aging. 2021-7

[2]
Structural and functional network mechanisms of rescuing cognitive control in aging.

Neuroimage. 2022-11-15

[3]
Research outside the laboratory: Longitudinal at-home neurostimulation.

Behav Brain Res. 2022-6-25

[4]
Assessing Cognitive Function in Multiple Sclerosis With Digital Tools: Observational Study.

J Med Internet Res. 2021-12-30

[5]
Cognitive control persistently enhances hippocampal information processing.

Nature. 2021-12

[6]
Individual differences in neuroanatomy and neurophysiology predict effects of transcranial alternating current stimulation.

Brain Stimul. 2021

[7]
Effects of Transcranial Alternating Current Stimulation and Neurofeedback on Alpha (EEG) Dynamics: A Review.

Front Hum Neurosci. 2021-7-8

[8]
Long-term maintenance of multitasking abilities following video game training in older adults.

Neurobiol Aging. 2021-7

[9]
Sustained benefits of cognitive training in children with inattention, three-year follow-up.

PLoS One. 2021

[10]
Modulation of auditory gamma-band responses using transcranial electrical stimulation.

J Neurophysiol. 2020-6-1

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