Canestrari F, Galli F, Gheller G, De Crescentini S, Biagiarelli B
Istituto di Chimica Biologica, U.S.L. N. 5 Urbino.
Boll Soc Ital Biol Sper. 1991 Jul;67(7):659-66.
In the present work we reported the results of the study of erythrocyte membrane Na+,K(+)-adenosine triphosphatase (ATPase) and Mg(2+)-ATPase in patients with essential hypertension and controls. In the 40 patients with hypertension, a more marked decrease of Na+, K(+)-ATPase was observed. The behavior of the enzyme at Mg2+ activation, ouabain inhibition and the response to different temperature suggest the possibility of differences between the two groups. The normal erythrocyte Mg(2+)-ATPase activity in two groups suggest also the possible role of ratio Na+, K(+)-ATPase/Mg(2+)-ATPase in the study of essential hypertension. However the relevance of magnesium and Mg(2+)-ATPase to the pathogenesis of essential hypertension remains unclear but merits further study. On the basis of these considerations the aim of the present study was to identify, in a kinetic approach, the presence of different abnormalities of Na+ transport and Na+, K(+)-ATPase in erythrocytes from patients with essential hypertension. Much evidence has supported the hypothesis that essential hypertension is a heterogeneous disease in the pathophysiological mechanisms as well as in its clinical and therapeutical consideration.
在本研究中，我们报告了对原发性高血压患者和对照组红细胞膜钠钾 - 腺苷三磷酸酶（ATP酶）及镁 - ATP酶的研究结果。在40例高血压患者中，观察到钠钾 - ATP酶有更显著的降低。该酶在镁离子激活、哇巴因抑制及不同温度下的表现提示两组之间可能存在差异。两组中正常的红细胞镁 - ATP酶活性也提示钠钾 - ATP酶/镁 - ATP酶比值在原发性高血压研究中可能具有作用。然而，镁及镁 - ATP酶与原发性高血压发病机制的相关性仍不清楚，但值得进一步研究。基于这些考虑，本研究的目的是以动力学方法确定原发性高血压患者红细胞中钠转运及钠钾 - ATP酶存在的不同异常情况。大量证据支持这样的假说，即原发性高血压在病理生理机制以及临床和治疗方面都是一种异质性疾病。
