Dada T, Mohan S, Sihota R, Gupta R, Gupta V, Pandey R M
Glaucoma Research Laboratory, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Eye (Lond). 2007 Jul;21(7):956-61. doi: 10.1038/sj.eye.6702360. Epub 2006 May 5.
To study changes in anterior segment morphology after laser peripheral iridotomy (LPI) in primary angle closure (PAC) and primary angle closure glaucoma (PACG) using ultrasound biomicroscopy (UBM).
Ninety-three eyes of 93 patients underwent anterior segment evaluation including gonioscopy, disc evaluation with + 90D lens, applanation intraocular pressure, and standard achromatic perimetry. UBM was performed before and 2 weeks after Nd:YAG LPI to measure the trabecular-iris angle (TIA), the angle-opening distance (AOD 250/500), and the central anterior chamber depth (ACD).
The superior TIA widened from a mean of 7.54+/-3.15 to 15.66+/-6.69 degrees (P=0.0001), the inferior TIA increased from a mean of 9.0+/-4.7 to 15.9+/-6.8 degrees (P=0.0001) after LPI in PAC. In PACG, the mean superior angle changed from 4.55+/-2.5 to 6.12+/-3.8 degrees (P=0.4) and the inferior angle increased from 4.75+/-2.0 to 7.9+/-3.7 degrees (P=0.1). The mean ACD increased from 2.19+/-0.36 to 2.30+/-0.36 mm in PAC group (P=0.0003), with no significant change seen in the PACG group (1.79+/-0.32 vs 1.82+/-0.33 mm, P=0.13).
LPI leads to a widening of the anterior chamber angle and a deepening of the anterior chamber in eyes with PAC. It does not significantly change any anterior segment parameters in eyes with PACG.
使用超声生物显微镜（UBM）研究原发性闭角型青光眼（PAC）和原发性闭角型青光眼（PACG）患者行激光周边虹膜切开术（LPI）后眼前节形态的变化。
对93例患者的93只眼进行眼前节评估，包括房角镜检查、用+90D透镜进行视盘评估、压平眼压测量和标准的无色视野检查。在Nd:YAG激光周边虹膜切开术前和术后2周进行UBM检查，以测量小梁-虹膜夹角（TIA）、房角开放距离（AOD 250/500）和中央前房深度（ACD）。
在PAC患者中，LPI术后上象限TIA从平均7.54±3.15度增宽至15.66±6.69度（P = 0.0001），下象限TIA从平均9.0±4.7度增加至15.9±6.8度（P = 0.0001）。在PACG患者中，上象限平均角度从4.55±2.5度变为6.12±3.8度（P = 0.4），下象限角度从4.75±2.0度增加至7.9±3.7度（P = 0.1）。PAC组平均ACD从2.19±0.36mm增加至2.30±0.36mm（P = 0.0003），PACG组未见明显变化（1.79±0.32mm对1.82±0.33mm，P = 0.13）。
LPI可使PAC患者的前房角增宽、前房加深。它不会使PACG患者的任何眼前节参数发生显著变化。
