Guerra Raquel Bezerra, Tostes Marcelo Duarte, da Costa Miranda Leandro, Pires de Camargo Olavo, Baptista André Mathias, Caiero Marcelo Tadeu, Dos Santos Machado Telma Muria, Abadi Márcia Datz, Mendes de Oliveira Claudia Regina G C M, Filippi Renée Zon
Institute of Orthepedics and Traumatology, Faculty of Medicine, University of São Paulo.
Clinics (Sao Paulo). 2006 Apr;61(2):99-106. doi: 10.1590/s1807-59322006000200003. Epub 2006 Apr 25.
The purposes of this study were to describe the early signs and symptoms of osteosarcoma and Ewing's sarcoma, identify symptoms that could be used to help differentiate the two types of tumors, and determine the time elapsed between the onset of signs and symptoms and the definitive diagnosis in our service, providing information and imputus for earlier diagnosis of these tumors.
A retrospective analysis of the medical dossiers of 365 patients under 30 years of age diagnosed with osteosarcoma or Ewing's sarcoma was performed, and the aspects of the clinical diagnosis were statistically analyzed and compared.
The time between the onset of signs and the symptoms was 5.25 months for osteosarcoma and 8.1 months for Ewing's sarcoma, and the most frequent (89.5%) early symptom of osteosarcoma and Ewing's sarcoma was local pain. Symptoms that might aid diagnosis included early local volume increase and the presence of fever.
The time until diagnosis of both neoplasias was higher than that reported for North America and Europe. Education of the lay public and medical professionals regarding suspicious early signs and symptoms might shorten the delay of diagnosis.
本研究的目的是描述骨肉瘤和尤因肉瘤的早期体征和症状，确定可用于帮助区分这两种肿瘤类型的症状，并确定在我们的医疗服务中从体征和症状出现到明确诊断所经过的时间，为这些肿瘤的早期诊断提供信息和依据。
对365例30岁以下诊断为骨肉瘤或尤因肉瘤的患者的医疗档案进行回顾性分析，并对临床诊断方面进行统计分析和比较。
骨肉瘤从体征和症状出现到确诊的时间为5.25个月，尤因肉瘤为8.1个月，骨肉瘤和尤因肉瘤最常见的（89.5%）早期症状是局部疼痛。可能有助于诊断的症状包括早期局部体积增大和发热。
这两种肿瘤确诊前的时间均高于北美和欧洲报告的时间。对公众和医学专业人员进行有关可疑早期体征和症状的教育可能会缩短诊断延迟。
