Sneppen O, Hansen L M
Acta Radiol Oncol. 1984;23(2-3):159-62. doi: 10.3109/02841868409136005.
Presenting symptoms and treatment delay were investigated in a series of 84 osteosarcomas and 40 Ewing's sarcomas. The treatment delay averaged 6.4 months for osteosarcomas and 9.6 months for Ewing's sarcomas. In both types the delay was relatively short in patients with constant pain and swelling. The prognosis was about the same whether the delay was short or long. This may be explained by the more severe nature of the presenting symptoms, in particular the constant pain and swelling, in aggressive tumours, a factor that also tends to mask other relevant prognostic parameters. It is concluded that the presenting symptoms and the treatment delay constitute important pathophysiologic factors which should be given more attention when analysing material from bone sarcomas.
对84例骨肉瘤和40例尤因肉瘤患者的首发症状及治疗延迟情况进行了调查。骨肉瘤的治疗延迟平均为6.4个月，尤因肉瘤为9.6个月。在这两种类型中，持续疼痛和肿胀的患者延迟相对较短。延迟时间长短，预后大致相同。这可能是由于侵袭性肿瘤首发症状的性质更为严重，尤其是持续疼痛和肿胀，这一因素也往往掩盖了其他相关的预后参数。结论是，首发症状和治疗延迟是重要的病理生理因素，在分析骨肉瘤资料时应给予更多关注。
