Bertanha Fernanda, Boufelli Gabriela, de Camargo Olavo Pires, Baptista André Mathias, Caiero Marcelo Tadeu, de Oliveira Claudia Regina G C M, Filippi Renée
Institute of Orthopedics and Traumatology, Hospital das Clínicas, São Paulo University Medical School, São Paulo, SP, Brazil.
Clinics (Sao Paulo). 2006 Apr;61(2):139-46. doi: 10.1590/s1807-59322006000200009. Epub 2006 Apr 25.
To evaluate the clinical aspects, diagnoses, prognostic factors, and percent progression of plasmacytoma to multiple myeloma.
103 medical records of patients suspected of plasmacytoma were surveyed covering the period between 1950 and 1998, and 30 were selected for analysis. Patients were classified into 2 groups: patients who did (n = 17) and did not (n = 13) progress to multiple myeloma. Comparative statistics regarding a variety of clinical aspects were developed.
Patients who progressed to multiple myeloma were younger than those who did not (52.3 +/- 2.6 vs 62.6 +/- 3.4 years; mean +/- SEM; P = 0.02). There were no significant differences in gender between groups. A higher incidence of multiple recurrence was observed in patients who progressed to multiple myeloma (75%, P = 0.049). Both groups showed a prevalence of vertebral column injuries. No significant differences were found between groups regarding the disease period (from the onset of symptoms until diagnosis) (P = 0.20) and survival (P = 0.34). The average time to progression from plasmacytoma to myeloma was 41 +/- 39 months (mean +/- SD), and the progression rate was 57%.
Patients who progressed to multiple myeloma were younger than those who did not. No significant differences were found between groups regarding sex, time from symptom onset to diagnosis, and survival time. In both groups, the most affected anatomic location was the vertebral column, and most affected sex was male. The average time to progression to multiple myeloma was 41 months. It was not possible to determine the factors that influenced the survival of patients with plasmacytoma or for those who progressed to multiple myeloma.
评估浆细胞瘤的临床特征、诊断、预后因素以及浆细胞瘤进展为多发性骨髓瘤的比例。
调查了1950年至1998年间103例疑似浆细胞瘤患者的病历，选取30例进行分析。将患者分为两组：进展为多发性骨髓瘤的患者（n = 17）和未进展为多发性骨髓瘤的患者（n = 13）。对各种临床特征进行了比较统计。
进展为多发性骨髓瘤的患者比未进展的患者年轻（52.3±2.6岁对62.6±3.4岁；平均值±标准误；P = 0.02）。两组间性别无显著差异。进展为多发性骨髓瘤的患者多次复发的发生率更高（75%，P = 0.049）。两组均以脊柱损伤为主。两组在疾病期（从症状出现到诊断）（P = 0.20）和生存率（P = 0.34）方面无显著差异。从浆细胞瘤进展为骨髓瘤的平均时间为41±39个月（平均值±标准差），进展率为57%。
进展为多发性骨髓瘤的患者比未进展的患者年轻。两组在性别、症状出现到诊断的时间以及生存时间方面无显著差异。两组中，最易受累的解剖部位是脊柱，最易受累的性别是男性。进展为多发性骨髓瘤的平均时间为41个月。无法确定影响浆细胞瘤患者或进展为多发性骨髓瘤患者生存的因素。
