Oleshko N N
Department of Physiology of Cerebral Cortex and Subcortical Structures, Bogomoletz Institute of Physiology, Kiev, USSR.
Acta Neurobiol Exp (Wars). 1991;51(3-4):129-33.
The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 5 mg/kg i.m. for 5 days) on the evoked activity of caudate neurones were studied extracellularly in ketamine-anaesthetized and myorelaxant-immobilized cats. Two days after the last MPTP injection the latency of caudate neurone responses to the motor cortex stimulation increased as compared to intact animals, due to a 10-fold decrease in the number of neurones with short-latency responses (from 1.8 up to 8.0 ms). At the same time, no essential changes were observed under the influence of MPTP in the distribution pattern of the latency of caudate neurone responses to the stimulation of the ventral anterior and ventral lateral nuclei of the thalamus. The suggestion that dopamine protects monosynaptic transmission of impulses from the cerebral cortex to neostriatum neurones is discussed.
在氯胺酮麻醉并使用肌松剂固定的猫身上，通过细胞外记录法研究了1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP，5毫克/千克，肌肉注射，连续5天）对尾状核神经元诱发活动的影响。在最后一次注射MPTP两天后，与正常动物相比，尾状核神经元对运动皮层刺激的反应潜伏期延长，这是因为短潜伏期反应的神经元数量减少了10倍（从1.8毫秒增加到8.0毫秒）。同时，在MPTP的影响下，未观察到尾状核神经元对丘脑腹前核和腹外侧核刺激的反应潜伏期分布模式有本质变化。文中讨论了多巴胺保护从大脑皮层到新纹状体神经元的单突触冲动传递这一观点。
