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[神经毒素MPTP诱发的猫尾状核神经元皮质离心脉冲串阻断的可逆性]

[The reversibility of a blockade of corticofugal pulse trains to the neurons of the caudate nucleus in cats evoked by the neurotoxin MPTP].

作者信息

Oleshko N N

出版信息

Fiziol Zh Im I M Sechenova. 1994 Jan;80(1):121-4.

PMID:7522752
Abstract

In anesthetised cats, the number of the caudate nucleus neurons responding to a cortical stimulation with latency less than 8.0 ms, increased within 10-12 days after the MPTP administration and then gradually recovers by the 45th-54th day after the neurotoxin administration. Dopamine seems to exert a protecting-inhibiting effect on transmission of corticofugal glutamatergic impulses travelling towards the neostriatum neurons.

摘要

在麻醉猫中,尾状核神经元对潜伏期小于8.0毫秒的皮质刺激产生反应的数量,在给予MPTP后的10 - 12天内增加,然后在给予神经毒素后的第45 - 54天逐渐恢复。多巴胺似乎对向新纹状体神经元传播的皮质下行谷氨酸能冲动的传递发挥保护抑制作用。

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