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[神经毒素MPTP诱发的猫尾状核神经元皮质离心脉冲串阻断的可逆性]

[The reversibility of a blockade of corticofugal pulse trains to the neurons of the caudate nucleus in cats evoked by the neurotoxin MPTP].

作者信息

Oleshko N N

出版信息

Fiziol Zh Im I M Sechenova. 1994 Jan;80(1):121-4.

PMID:7522752
Abstract

In anesthetised cats, the number of the caudate nucleus neurons responding to a cortical stimulation with latency less than 8.0 ms, increased within 10-12 days after the MPTP administration and then gradually recovers by the 45th-54th day after the neurotoxin administration. Dopamine seems to exert a protecting-inhibiting effect on transmission of corticofugal glutamatergic impulses travelling towards the neostriatum neurons.

摘要

在麻醉猫中，尾状核神经元对潜伏期小于8.0毫秒的皮质刺激产生反应的数量，在给予MPTP后的10 - 12天内增加，然后在给予神经毒素后的第45 - 54天逐渐恢复。多巴胺似乎对向新纹状体神经元传播的皮质下行谷氨酸能冲动的传递发挥保护抑制作用。

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1
[The reversibility of a blockade of corticofugal pulse trains to the neurons of the caudate nucleus in cats evoked by the neurotoxin MPTP].[神经毒素MPTP诱发的猫尾状核神经元皮质离心脉冲串阻断的可逆性]
Fiziol Zh Im I M Sechenova. 1994 Jan;80(1):121-4.
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Reversible blockade, induced by the neurotoxin MPTP, of corticofugal impulse activity to neurons of the caudate nucleus in cats.猫中由神经毒素MPTP诱导的对尾状核神经元的皮质离心冲动活动的可逆性阻断。
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A loss of short-latency excitatory caudate unitary responses to motor cortex but not to motor thalamic nuclei stimulation in MPTP-treated cats.在经MPTP处理的猫中，尾状核对运动皮层刺激的短潜伏期兴奋性单一反应丧失，但对运动丘脑核刺激的反应未丧失。
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引用本文的文献

1
Morphofunctional studies of the interactions of the glutamatergic, cholinergic, and dopaminergic systems in the neostriatum.
Neurosci Behav Physiol. 1998 Jul-Aug;28(4):397-401. doi: 10.1007/BF02464794.