Esteban F, Muñoz M, González-Moles M A, Rosso M
Hospital Universitario Virgen del Rocío de Sevilla, Universidad de Sevilla, Spain.
Cancer Metastasis Rev. 2006 Mar;25(1):137-45. doi: 10.1007/s10555-006-8161-9.
In the present review we discuss a central role for substance P (SP) in carcinogenesis. We suggest that one mechanism to induce mitogenesis of tumor cells is the activation of neurokinin-1 receptor (NK1R) through SP, linking cancer promotion and progression to a neurokinin-mediated environment. After reviewing the role of both SP and its receptor NK1R in normal and neoplastic cells we propose the use of neurokinin-1 receptor antagonists as a novel and promising approach for treating patients with cancer.
在本综述中，我们讨论了P物质（SP）在致癌作用中的核心作用。我们认为，诱导肿瘤细胞有丝分裂的一种机制是通过SP激活神经激肽-1受体（NK1R），将癌症的促进和进展与神经激肽介导的环境联系起来。在回顾了SP及其受体NK1R在正常细胞和肿瘤细胞中的作用后，我们提出使用神经激肽-1受体拮抗剂作为一种治疗癌症患者的新颖且有前景的方法。
