Advincula Maria C, Petersen Don, Rahemtulla Firoz, Advincula Rigoberto, Lemons Jack E
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
J Biomed Mater Res B Appl Biomater. 2007 Jan;80(1):107-20. doi: 10.1002/jbm.b.30575.
Surfaces of biocompatible alloys used as implants play a significant role in their osseointegration. Surface sol-gel processing (SSP), a variant of the bulk sol-gel technique, is a relatively new process to prepare bioreactive nanostructured titanium oxide for thin film coatings. The surface topography, roughness, and composition of sol-gel processed Ti6Al4V titanium alloy coatings was investigated by atomic force microscopy (AFM) and X-ray electron spectroscopy (XPS). This was correlated with corrosion properties, adhesive strength, and bioreactivity in simulated body fluids (SBF). Electroimpedance spectroscopy (EIS) and polarization studies indicated similar advantageous corrosion properties between sol-gel coated and uncoated Ti6Al4V, which was attributed to the stable TiO2 composition, topography, and adhesive strength of the sol-gel coating. In addition, inductive coupled plasma (ICP) and scanning electron microscopy with energy dispersive spectrometry (SEM-EDS) analysis of substrates immersed in SBF revealed higher deposition of calcium and phosphate and low release rates of alloying elements from the sol-gel modified alloys. The equivalent corrosion behavior and the definite increase in nucleation of calcium apatite indicate the potential of the sol-gel coating for enhanced bioimplant applications.
用作植入物的生物相容性合金表面在其骨整合过程中起着重要作用。表面溶胶 - 凝胶处理（SSP）是本体溶胶 - 凝胶技术的一种变体，是一种制备用于薄膜涂层的生物活性纳米结构二氧化钛的相对较新的工艺。通过原子力显微镜（AFM）和X射线电子能谱（XPS）研究了溶胶 - 凝胶处理的Ti6Al4V钛合金涂层的表面形貌、粗糙度和成分。这与模拟体液（SBF）中的腐蚀性能、粘附强度和生物活性相关。电化学阻抗谱（EIS）和极化研究表明，溶胶 - 凝胶涂层和未涂层的Ti6Al4V之间具有相似的有利腐蚀性能，这归因于溶胶 - 凝胶涂层稳定的TiO2成分、形貌和粘附强度。此外，对浸泡在SBF中的基材进行电感耦合等离子体（ICP）和带有能量色散光谱的扫描电子显微镜（SEM - EDS）分析，结果显示溶胶 - 凝胶改性合金中钙和磷的沉积更高，合金元素的释放速率更低。等效的腐蚀行为以及钙磷灰石成核的明显增加表明溶胶 - 凝胶涂层在增强生物植入物应用方面的潜力。
