杂合子血色素沉着症患者的血清非转铁蛋白结合铁与低密度脂蛋白氧化

Serum non-transferrin-bound iron and low-density lipoprotein oxidation in heterozygous hemochromatosis.

作者信息

van Tits Lambertus J H, Jacobs Esther M G, Swinkels Dorine W, Lemmers Heidi L M, van der Vleuten Gerly M, de Graaf Jacqueline, Stalenhoef Anton F H

机构信息

Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

出版信息

Biochem Biophys Res Commun. 2006 Jun 23;345(1):371-6. doi: 10.1016/j.bbrc.2006.04.100. Epub 2006 May 2.

DOI:10.1016/j.bbrc.2006.04.100

PMID:16682004

Abstract

UNLABELLED

Non-transferrin-bound iron (NTBI) is implicated in lipid peroxidation but the relation with oxidative modification of low-density lipoprotein (LDL) is not known. We assessed variables reflecting in vitro and in vivo LDL oxidation in two age- and sex-matched groups (n=23) of hereditary hemochromatosis heterozygotes (C282Y), characterized by a clear difference in mean serum NTBI (1.55+/-0.57 micromol/L vs 3.70+/-0.96 micromol/L). Plasma level of oxidized LDL (absolute and relative to plasma apolipoprotein B), and IgG and IgM antibodies to oxidized LDL, markers of in vivo LDL oxidation, did not differ between the groups with low and high serum NTBI. Mean lag-phase of in vitro LDL oxidation was also not significantly different between both study groups.

CONCLUSION

these findings do not support the hypothesis that NTBI promotes oxidative modification of plasma LDL.

摘要

未标记

非转铁蛋白结合铁（NTBI）与脂质过氧化有关，但与低密度脂蛋白（LDL）氧化修饰的关系尚不清楚。我们评估了反映体外和体内LDL氧化的变量，这两个变量来自两组年龄和性别匹配的遗传性血色素沉着症杂合子（C282Y）（n = 23），其特征是平均血清NTBI存在明显差异（1.55±0.57微摩尔/升对3.70±0.96微摩尔/升）。血清NTBI水平低和高的两组之间，氧化LDL的血浆水平（相对于血浆载脂蛋白B的绝对值和相对值）以及针对氧化LDL的IgG和IgM抗体（体内LDL氧化的标志物）没有差异。两个研究组之间体外LDL氧化的平均滞后期也没有显著差异。