Takahashi Yoshihisa, Fukushima Jun-Ichi, Fukusato Toshio, Mori Shigeo
Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
Pathol Res Pract. 2006;202(7):549-53. doi: 10.1016/j.prp.2006.03.001. Epub 2006 May 8.
A case of ileal adenomyoma with goblet and Paneth cells is reported. A 75-year-old man died of ruptured hepatocellular carcinoma. As an incidental finding at autopsy, a 9 x 7 x 6 mm(3)-sized nodule was found in the ileal wall. Histologically, the lesion occupied the submucosa and muscularis propria, and consisted of glandular structures of various sizes and interlacing smooth muscle bundles surrounding the glandular elements. Goblet cells and Paneth cells were interspersed in the glandular element. Immunohistochemically, the glandular element was positive for cytokeratin (CK) 7 and negative for CK 20. This is the first reported case of adenomyoma of the gastrointestinal tract that contained Paneth cells. The result of the immunohistochemical staining favored the heterotopic pancreas theory concerning its pathogenesis. The appearance of goblet and Paneth cells might be the result of metaplasia.
报告了一例含有杯状细胞和潘氏细胞的回肠腺肌瘤病例。一名75岁男性死于肝细胞癌破裂。尸检时偶然发现，回肠壁有一个大小为9×7×6mm³的结节。组织学上，病变占据黏膜下层和固有肌层，由大小不一的腺管结构和围绕腺管成分的交错平滑肌束组成。杯状细胞和潘氏细胞散在于腺管成分中。免疫组化显示，腺管成分细胞角蛋白（CK）7阳性，CK20阴性。这是首例报道的含有潘氏细胞的胃肠道腺肌瘤病例。免疫组化染色结果支持其发病机制的异位胰腺理论。杯状细胞和潘氏细胞的出现可能是化生的结果。
