传统放疗对头颈部健康相关生活质量和关键功能的影响。
Impact of conventional radiotherapy on health-related quality of life and critical functions of the head and neck.
作者信息
Connor Nadine P, Cohen Stacy B, Kammer Rachael E, Sullivan Paula A, Brewer Kathryn A, Hong Theodore S, Chappell Richard J, Harari Paul M
机构信息
Department of Otolaryngology-Head & Neck Surgery, University of Wisconsin Medical School, and William S. Middleton Memorial Veterans Hospital, Madison, WI 53792-7375, USA.
出版信息
Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1051-62. doi: 10.1016/j.ijrobp.2006.01.054. Epub 2006 May 6.
PURPOSE
Head-and-neck radiotherapy is associated with significant morbidities. Our purpose was to document impact of morbidities by use of multiple objective measures and health-related quality of life (HR-QOL).
METHODS AND MATERIALS
Ten head-and-neck cancer patients were evaluated before receiving conventional head-and-neck radiotherapy and at 1 month and 6 months after treatment. We evaluated weight, saliva production, diet, swallow function, auditory function, and HR-QOL.
RESULTS
After radiotherapy, weight was reduced in 89% of subjects. Salivary function was significantly reduced and did not resolve by 6 months. Diet impairment and abnormalities in swallowing function persisted at 6 months. Perception of physical functioning was reduced after treatment, and swallowing, coughing, and dry-mouth symptoms increased. Very few changes were observed in auditory function.
CONCLUSIONS
Conventional head-and-neck radiotherapy is associated with substantial functional deficits and diminished HR-QOL. Deficits reported here can serve as a baseline for comparison with results derived from new radiotherapy-treatment techniques.
目的
头颈部放疗会引发显著的并发症。我们的目的是通过使用多种客观测量方法和健康相关生活质量（HR-QOL）来记录并发症的影响。
方法与材料
对10名头颈部癌症患者在接受传统头颈部放疗前、治疗后1个月和6个月进行评估。我们评估了体重、唾液分泌、饮食、吞咽功能、听觉功能和HR-QOL。
结果
放疗后，89%的受试者体重减轻。唾液功能显著降低，且在6个月时仍未恢复。饮食障碍和吞咽功能异常在6个月时持续存在。治疗后身体功能的感知下降，吞咽、咳嗽和口干症状增加。听觉功能几乎没有变化。
结论
传统头颈部放疗会导致大量功能缺陷并降低HR-QOL。此处报告的缺陷可作为与新放疗治疗技术结果进行比较的基线。
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