Connor Nadine P, Cohen Stacy B, Kammer Rachael E, Sullivan Paula A, Brewer Kathryn A, Hong Theodore S, Chappell Richard J, Harari Paul M
Department of Otolaryngology-Head & Neck Surgery, University of Wisconsin Medical School, and William S. Middleton Memorial Veterans Hospital, Madison, WI 53792-7375, USA.
Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1051-62. doi: 10.1016/j.ijrobp.2006.01.054. Epub 2006 May 6.
Head-and-neck radiotherapy is associated with significant morbidities. Our purpose was to document impact of morbidities by use of multiple objective measures and health-related quality of life (HR-QOL).
Ten head-and-neck cancer patients were evaluated before receiving conventional head-and-neck radiotherapy and at 1 month and 6 months after treatment. We evaluated weight, saliva production, diet, swallow function, auditory function, and HR-QOL.
After radiotherapy, weight was reduced in 89% of subjects. Salivary function was significantly reduced and did not resolve by 6 months. Diet impairment and abnormalities in swallowing function persisted at 6 months. Perception of physical functioning was reduced after treatment, and swallowing, coughing, and dry-mouth symptoms increased. Very few changes were observed in auditory function.
Conventional head-and-neck radiotherapy is associated with substantial functional deficits and diminished HR-QOL. Deficits reported here can serve as a baseline for comparison with results derived from new radiotherapy-treatment techniques.
头颈部放疗会引发显著的并发症。我们的目的是通过使用多种客观测量方法和健康相关生活质量（HR-QOL）来记录并发症的影响。
对10名头颈部癌症患者在接受传统头颈部放疗前、治疗后1个月和6个月进行评估。我们评估了体重、唾液分泌、饮食、吞咽功能、听觉功能和HR-QOL。
放疗后，89%的受试者体重减轻。唾液功能显著降低，且在6个月时仍未恢复。饮食障碍和吞咽功能异常在6个月时持续存在。治疗后身体功能的感知下降，吞咽、咳嗽和口干症状增加。听觉功能几乎没有变化。
传统头颈部放疗会导致大量功能缺陷并降低HR-QOL。此处报告的缺陷可作为与新放疗治疗技术结果进行比较的基线。
