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某些3-取代-2-(4-甲基-1-哌嗪基)-4-苯基喹啉的合成及5-羟色胺受体结合研究

Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines.

作者信息

Anzini M, Cappelli A, Vomero S, Campiani G, Cagnotto A, Skorupska M

机构信息

Dipartimento Farmaco Chimico Tecnologico-Università, Siena, Italy.

出版信息

Farmaco. 1991 Dec;46(12):1435-47.

PMID:1668253
Abstract

The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.

摘要

报道了一些3-取代-2-(4-甲基-1-哌嗪基)-4-苯基喹啉的合成。对标题化合物在5-羟色胺（5-HT）受体亚型和5-HT摄取位点上的潜在活性进行了测试；化合物4b-d对5-HT3和5-HT摄取位点显示出微摩尔级亲和力。

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