某些4-苯基喹啉衍生物的合成及其对5-羟色胺受体的亲和力
Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives.
作者信息
Anzini M, Vomero S, Garofalo A, Cappelli A, Cagnotto A
机构信息
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy.
出版信息
Farmaco. 1989 Jun;44(6):555-63.
PMID:2529861
Abstract
The synthesis of a series of 4-phenylquinolines with substituents in 2,3 and 6-position of the quinoline nucleus is described. Serotoninergic activity towards 5HT1A, 5HT1B, 5HT2, 5HT1A + B receptors and the 5-HT-uptake site was also studied.
摘要
本文描述了一系列在喹啉核的2、3和6位带有取代基的4-苯基喹啉的合成。还研究了其对5HT1A、5HT1B、5HT2、5HT1A + B受体以及5-羟色胺摄取位点的血清素能活性。
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