Halma C, Daha M R, van der Meer J W, Cohen A, van Furth R, Breedveld F C, Evers-Schouten J H, Pauwels E K, van Es L A
Department of Nephrology, University Hospital Leiden, The Netherlands.
J Clin Lab Immunol. 1991 May;35(1):9-15.
Serum concentrations of IgG may influence Fc receptor-mediated clearance of immune complexes. For instance, when 123I-labeled aggregates of human IgG (123I-AIgG), used as a model for soluble immune complexes, are administered to patients with systemic lupus erythematosus (SLE), there is an inverse correlation between the serum concentrations of IgG and the clearance and volume of distribution in steady state (Vss) of 123I-AIgG. To answer the question whether IgG has a direct effect on the clearance of immune complexes, we measured the elimination of 123I-AIgG in eight patients with hypogammaglobulinemia, before and after substitution with intravenous gammaglobulin (IVIG). As expected, raising IgG concentrations in these patients (by 6 g/l) caused a significant decrease of the Vss of 123I-AIgG. However, clearance of 123I-AIgG remained unchanged by IVIG. Thus, the results of this study offer no experimental evidence that raising concentrations of IgG influences the clearance of soluble immune complexes.
血清IgG浓度可能会影响Fc受体介导的免疫复合物清除。例如，当将作为可溶性免疫复合物模型的123I标记的人IgG聚集体（123I-AIgG）给予系统性红斑狼疮（SLE）患者时，IgG血清浓度与123I-AIgG稳态清除率及分布容积（Vss）之间呈负相关。为了回答IgG是否对免疫复合物清除有直接影响这一问题，我们在8例低丙种球蛋白血症患者静脉注射丙种球蛋白（IVIG）替代治疗前后，测量了123I-AIgG的清除情况。正如预期的那样，这些患者的IgG浓度升高（升高6 g/l）导致123I-AIgG的Vss显著降低。然而，IVIG并未改变123I-AIgG的清除率。因此，本研究结果没有提供实验证据表明提高IgG浓度会影响可溶性免疫复合物的清除。
