人体内可溶性123I标记的人免疫球蛋白G聚集体的清除；脾切除术的影响。
Elimination of soluble 123I-labelled aggregates of human immunoglobulin G in humans; the effect of splenectomy.
作者信息
Halma C, Daha M R, van Furth R, Camps J A, Evers-Schouten J H, Pauwels E K, Lobatto S, Van Es L A
机构信息
Department of Nephrology, University Hospital Leiden, The Netherlands.
出版信息
Clin Exp Immunol. 1989 Jul;77(1):62-6.
Abstract
To study the role of the spleen in the elimination of immune complexes we examined mononuclear phagocyte system function in eight healthy controls and eight splenectomized patients, with soluble 123I-labelled aggregates of human immunoglobulin G (AIgG). No differences were found between the two groups in elimination and degradation of AIgG. The loss of splenic function was compensated for by increased uptake of AIgG by the liver. With the dose of 123I-AIgG used in this study (10 micrograms/kg body weight), significant generation of C3a was observed. No correlation was found between erythrocyte CR1 number and the fraction of aggregates that bound to erythrocytes.
摘要
为研究脾脏在清除免疫复合物中的作用，我们用可溶性123I标记的人免疫球蛋白G聚合体（AIgG）检测了8名健康对照者和8名脾切除患者的单核吞噬细胞系统功能。两组在AIgG的清除和降解方面未发现差异。脾脏功能的丧失通过肝脏对AIgG摄取的增加得到了补偿。在本研究使用的123I - AIgG剂量（10微克/千克体重）下，观察到了C3a的显著生成。红细胞CR1数量与结合到红细胞上的聚合体比例之间未发现相关性。
相似文献
1
Elimination of soluble 123I-labelled aggregates of human immunoglobulin G in humans; the effect of splenectomy.人体内可溶性123I标记的人免疫球蛋白G聚集体的清除；脾切除术的影响。
Clin Exp Immunol. 1989 Jul;77(1):62-6.
2
Abnormal clearance of soluble aggregates of human immunoglobulin G in patients with systemic lupus erythematosus.系统性红斑狼疮患者体内人免疫球蛋白G可溶性聚集体的清除异常。
Clin Exp Immunol. 1988 Apr;72(1):55-9.
3
Clearance of soluble aggregates of human immunoglobulin G in healthy volunteers and chimpanzees.健康志愿者和黑猩猩体内人免疫球蛋白G可溶性聚集体的清除情况。
Clin Exp Immunol. 1987 Jul;69(1):133-41.
4
Effect of monomeric immunoglobulin G (IgG) on the clearance of soluble aggregates of IgG in man.单体免疫球蛋白G（IgG）对人体中IgG可溶性聚集体清除的影响。
J Clin Lab Immunol. 1991 May;35(1):9-15.
5
Binding and catabolism of aggregated immunoglobulins bearing C3b or iC3b by U937 cells.U937细胞对携带C3b或iC3b的聚集免疫球蛋白的结合与分解代谢
Immunology. 1988 Jul;64(3):375-9.
6
Deficiency of complement component C3 is associated with accelerated removal of soluble 123I-labelled aggregates of IgG from the circulation.补体成分C3缺乏与循环中可溶性123I标记的IgG聚集体的清除加速有关。
Clin Exp Immunol. 1992 Dec;90(3):394-400. doi: 10.1111/j.1365-2249.1992.tb05857.x.
7
8
Complement enhances the elimination of soluble aggregates of IgG by rat liver endothelial cells in vivo.
Eur J Immunol. 1993 Feb;23(2):433-8. doi: 10.1002/eji.1830230220.
9
10
Diminished clearance of soluble aggregates of human immunoglobulin G in patients with rheumatoid arthritis.类风湿关节炎患者体内人免疫球蛋白G可溶性聚集体的清除率降低。
Scand J Rheumatol. 1989;18(2):89-96. doi: 10.3109/03009748909099923.
引用本文的文献
1
Investigation of the mechanism of clearance of AMG 386, a selective angiopoietin-1/2 neutralizing peptibody, in splenectomized, nephrectomized, and FcRn knockout rodent models.研究选择性血管生成素-1/2 中和肽 AMG 386 在脾切除、肾切除和 FcRn 敲除啮齿动物模型中的清除机制。
Pharm Res. 2012 Apr;29(4):1057-65. doi: 10.1007/s11095-011-0650-z. Epub 2011 Dec 22.
2
Complement deficiency and immune complex disease.补体缺陷与免疫复合物疾病
Springer Semin Immunopathol. 1994;15(4):397-416. doi: 10.1007/BF01837367.
3
Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells.体内库普弗细胞耗竭会导致通过大鼠肝内皮细胞上的特异性Fc受体优先清除IgG聚集体和免疫复合物。
Clin Exp Immunol. 1991 Nov;86(2):328-33. doi: 10.1111/j.1365-2249.1991.tb05818.x.
4
Immune adherence and clearance of hepatitis B surface Ag/Ab complexes is abnormal in patients with systemic lupus erythematosus (SLE).系统性红斑狼疮（SLE）患者体内乙肝表面抗原/抗体复合物的免疫黏附及清除功能异常。
Clin Exp Immunol. 1991 Sep;85(3):373-8. doi: 10.1111/j.1365-2249.1991.tb05734.x.
本文引用的文献
1
Evaluation of aggregated IgG in mice as an Fc receptor specific probe of the hepatic mononuclear phagocyte system.评估小鼠体内聚集的IgG作为肝单核吞噬细胞系统的Fc受体特异性探针。
Clin Exp Immunol. 1982 Jul;49(1):200-8.
2
Primate erythrocyte-immune complex-clearing mechanism.灵长类动物红细胞免疫复合物清除机制。
J Clin Invest. 1983 Feb;71(2):236-47. doi: 10.1172/jci110764.
3
The detection of circulating immune complexes containing immunoglobulin G.含有免疫球蛋白G的循环免疫复合物的检测。
J Clin Lab Immunol. 1984 Jun;14(2):73-9.
4
Complement depletion accelerates the clearance of immune complexes from the circulation of primates.补体耗竭加速免疫复合物从灵长类动物循环系统中的清除。
J Clin Invest. 1984 Oct;74(4):1329-40. doi: 10.1172/JCI111543.
5
6
The glomerular mesangium. I. Kinetic studies of macromolecular uptake in normal and nephrotic rats.肾小球系膜。I. 正常和肾病大鼠中大分子摄取的动力学研究。
J Clin Invest. 1972 May;51(5):1092-101. doi: 10.1172/JCI106901.
7
The localization of aggregated human -globulin in the spleens of normal mice.聚集的人β球蛋白在正常小鼠脾脏中的定位。
Immunology. 1973 Jun;24(6):955-68.
8
Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo. Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli.免疫球蛋白A和免疫球蛋白G1免疫复合物在体内与灵长类红细胞的差异性结合。免疫球蛋白A免疫复合物与红细胞的结合较差，且优先沉积于肾小球。
J Clin Invest. 1986 Jan;77(1):82-9. doi: 10.1172/JCI112306.
9
Difference in clearance kinetics of particulate immune complexes and soluble aggregates of IgG in vivo.体内颗粒性免疫复合物与IgG可溶性聚集体清除动力学的差异。
Clin Immunol Immunopathol. 1986 Dec;41(3):379-91. doi: 10.1016/0090-1229(86)90008-5.
10
Clearance of soluble aggregates of human immunoglobulin G in healthy volunteers and chimpanzees.健康志愿者和黑猩猩体内人免疫球蛋白G可溶性聚集体的清除情况。
Clin Exp Immunol. 1987 Jul;69(1):133-41.
Zotero 插件