Ferreres J R, Marcoval J, Bordas X, Moreno A, Muniesa C, Prat C, Peyrí J
Department of Dermatology, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain.
J Eur Acad Dermatol Venereol. 2006 May;20(5):599-601. doi: 10.1111/j.1468-3083.2006.01579.x.
Calciphylaxis is an uncommon disease characterized by calcification of dermal vessels that determines skin necrosis. Calciphylaxis has been almost exclusively reported in association with renal failure and altered phosphor-calcium metabolism. Only a few cases have been described in hyperparathyroidism, malignancies, and, recently, cirrhosis. We report a patient that developed calciphylaxis related to end-stage alcoholic cirrhosis, without any alteration in the phosphocalcic and parathyroid hormone metabolisms. Possible contributing factors were repeated albumin infusions and low levels of protein C and S.
钙化防御是一种罕见疾病，其特征为真皮血管钙化，进而导致皮肤坏死。钙化防御几乎仅见于与肾衰竭及磷钙代谢改变相关的情况。仅少数病例见于甲状旁腺功能亢进、恶性肿瘤，以及最近报道的肝硬化。我们报告了1例与终末期酒精性肝硬化相关的钙化防御患者，其磷钙及甲状旁腺激素代谢无任何改变。可能的促成因素为反复输注白蛋白以及蛋白C和S水平低下。
