Fernandez Kristen H, Liu Vincent, Swick Brian L
Department of Dermatology, University of Missouri, Columbia, MO 65212, USA.
Am J Dermatopathol. 2013 Feb;35(1):106-8. doi: 10.1097/DAD.0b013e31826330db.
Calciphylaxis is a rare condition characterized by medial calcification of small- and medium-sized vessels that subsequently leads to ischemic necrosis. Calciphylaxis most often occurs in patients with end-stage renal disease and secondary hyperparathyroidism. We present a unique case of calciphylaxis in which the patient did not have end-stage renal disease. Instead, primary hyperparathyroidism and/or alcoholic cirrhosis were the more likely causes of her calciphylaxis. In addition, our case demonstrated not only calciphylaxis but also fragmentation and calcification of elastic fibers within the dermis, changes that are most often seen in pseudoxanthoma elasticum. This is the first reported case of calciphylaxis, to our knowledge, with histopathologic changes of pseudoxanthoma elasticum in a patient who is nonuremic.
钙过敏是一种罕见病症，其特征为中小血管的中层钙化，随后导致缺血性坏死。钙过敏最常发生于终末期肾病和继发性甲状旁腺功能亢进患者。我们报告了一例独特的钙过敏病例，该患者并无终末期肾病。相反，原发性甲状旁腺功能亢进和/或酒精性肝硬化更有可能是其钙过敏的病因。此外，我们的病例不仅显示出钙过敏，还出现了真皮内弹性纤维的断裂和钙化，这些变化在弹性假黄瘤中最为常见。据我们所知，这是首例报道的非尿毒症患者出现弹性假黄瘤组织病理学改变的钙过敏病例。
