Dehal Shangara S
Discovery Labware, Woburn, MA 01545, USA.
Drug Metab Rev. 2006;38(1-2):13-22. doi: 10.1080/03602530600569786.
I worked with the late Dr. David Kupfer for nearly nine years at the Worcester Foundation/University of Massachusetts Medical School, Worcester, MA. I was involved in the metabolism of methoxychlor and tamoxifen, the areas of research close to David's heart. We demonstrated the metabolic pathways of these compounds in rats and humans, and the covalent binding to microsomal proteins that could result in long-term toxic manifestations. I learned a lot from David, who was a mentor and friend/colleague. His death has left a void in my heart and he will be sorely missed.
我在马萨诸塞州伍斯特市的伍斯特基金会/马萨诸塞大学医学院与已故的大卫·库普弗博士共事了近九年。我参与了甲氧滴滴涕和他莫昔芬的代谢研究，这些都是大卫极为关注的研究领域。我们在大鼠和人类身上证明了这些化合物的代谢途径，以及它们与微粒体蛋白的共价结合，这种结合可能导致长期的毒性表现。我从大卫身上学到了很多，他既是我的导师，也是我的朋友和同事。他的离世让我心中留下了一片空白，我会非常怀念他。
