Katkov A I, Semenenko T A, Vasil'eva V I
Voen Med Zh. 1991 Nov(11):35-7.
The analysis of influence in multiple injections of immunoglobulin (IG) on a level of morbidity and the efficiency of IG prophylaxis against hepatitis A in organized collectives made it possible to reveal the following common features: there is a direct dependency between morbidity level and average geometrical anti-IG titers, as well as the number of injections; there is inverse dependency between IG protection activity and the same factors; there is a lack of prophylaxis effect in anti-IG titers 1:32 or more. The authors frame a hypothesis that the reason of epidemic upgrowth of long standing hepatitis A morbidity dynamics in military collectives was conditioned by the wide application of IG in the 70s for children and teenagers.
对免疫球蛋白（IG）多次注射对发病率水平的影响以及IG在有组织群体中预防甲型肝炎效率的分析，得以揭示以下共同特征：发病率水平与平均几何抗IG滴度以及注射次数之间存在直接相关性；IG保护活性与相同因素之间存在负相关性；抗IG滴度为1:32或更高时缺乏预防效果。作者提出一个假设，即军队群体中甲型肝炎长期发病动态流行增长的原因，是70年代对儿童和青少年广泛应用IG。
