Osa T, Inoue H, Okabe K
Department of Physiology, School of Medicine, Yamaguchi University, Ube.
J Smooth Muscle Res. 1991 Feb;27(1):67-74. doi: 10.1540/jsmr.27.67.
The research on intracellular signal transduction and the smooth muscle contraction have made much progress since 1970. Effects of relaxin, a peptide hormone mainly produced and released from ovary, are reviewed in the above point of view. Cyclic AMP content in myometrial cells is increased by relaxin. One site of relaxin action can be the suppression of myosin light chain kinase activity. Another effect of relaxin is the suppression of action potential, whereby the Ca-influx is reduced. However, relaxin up to 300 mU does not hyperpolarize the myometrial membrane of estrogen-primed rat, which differs from the adrenergic beta-action. Unrealed signal transduction seems involved in the relaxin action.
自1970年以来，关于细胞内信号转导和平滑肌收缩的研究取得了很大进展。从上述观点出发，综述了主要由卵巢产生和释放的肽类激素松弛素的作用。松弛素可增加子宫肌层细胞中的环磷酸腺苷含量。松弛素的一个作用位点可能是抑制肌球蛋白轻链激酶活性。松弛素的另一个作用是抑制动作电位，从而减少钙内流。然而，高达300 mU的松弛素并不会使雌激素预处理大鼠的子宫肌层膜超极化，这与肾上腺素能β作用不同。未揭示的信号转导似乎参与了松弛素的作用。
