Szlachter N, O'Byrne E, Goldsmith L, Steinetz B G, Weiss G
Am J Obstet Gynecol. 1980 Mar 1;136(5):584-6. doi: 10.1016/0002-9378(80)91007-8.
Relaxin is a peptide hormone secreted by the human corpus luteum of pregnancy . Aqueous extracts of relaxin-rich pregnancy corpora lutea decreased the amplitude of spontaneous human myometrial strip contractions in vitro. Relaxin-poor extracts of menstrual cycle corpora lutea did not affect contractions. Antibody precipitation of relaxin from pregnancy luteal extracts eliminated the effect on myometrial strips. Relaxin removal was confirmed by bioassay. This demonstrates an inhibiting action of human relaxin on human myometrial tissue in vitro. This action suggests a mechanism for maintaining uterine quiesence in early pregnancy.
松弛素是一种由妊娠时的人体黄体分泌的肽类激素。富含松弛素的妊娠黄体的水提取物在体外可降低人体子宫肌条自发收缩的幅度。月经周期黄体的松弛素含量低的提取物对收缩没有影响。从妊娠黄体提取物中用抗体沉淀松弛素可消除对子宫肌条的作用。通过生物测定证实了松弛素已被去除。这证明了人体松弛素在体外对人体子宫肌组织具有抑制作用。这种作用提示了一种在妊娠早期维持子宫静止的机制。
