Zacharia A, Zimine S, Lovblad K O, Warfield S, Thoeny H, Ozdoba C, Bossi E, Kreis R, Boesch C, Schroth G, Hüppi P S
Neuroradiology Unit, Radiology Department, Geneva University, Switzerland.
AJNR Am J Neuroradiol. 2006 May;27(5):972-7.
We evaluated the impact of premature extrauterine life on brain maturation.
Twelve neonates underwent MR imaging at 40 (39.64 +/- 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 +/- 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compared with intracranial volume: total brain volume, cortical gray matter, myelinated white matter, unmyelinated white matter, basal ganglia (BG), and CSF.
The average absolute volume of intracranial volume (269.8 mL +/- 36.5), total brain volume (246.5 +/- 32.3), cortical gray matter (85.53 mL +/- 22.23), unmyelinated white matter (142.4 mL +/-14.98), and myelinated white matter (6.099 mL +/-1.82) for preterm at birth was significantly lower compared with that for the preterm at term: the average global volume of intracranial volume (431.7 +/- 69.98), total brain volume (391 +/- 66,1), cortical gray matter (179 mL +/- 41.54), unmyelinated white matter (185.3 mL +/- 30.8), and myelinated white matter (10.66 mL +/- 3.05). It was also lower compared with that of full-term infants: intracranial volume (427.4 mL +/- 53.84), total brain volume (394 +/- 49.22), cortical gray matter (181.4 +/- 29.27), unmyelinated white matter (183.4 +/- 27.37), and myelinated white matter (10.72 +/- 4.63). The relative volume of cortical gray matter (30.62 +/- 5.13) and of unmyelinated white matter (53.15 +/- 4.8) for preterm at birth was significantly different compared with the relative volume of cortical gray matter (41.05 +/- 5.44) and of unmyelinated white matter (43.22 +/- 5.11) for the preterm at term. Premature infants had similar brain tissue volumes at 40 weeks to full-term infants.
MR segmentation techniques demonstrate that cortical neonatal maturation in moderately premature infants at term and term-born infants was similar.
我们评估了宫外过早生活对脑成熟的影响。
12名新生儿在40（39.64±0.98）周（足月）时接受了磁共振成像（MR成像）检查。15名早产儿在出生后（出生时早产）和40周（41.03±1.33）（足月时早产）接受了2次MR成像检查。采用三维MR成像技术测量脑体积与颅内体积之比：全脑体积、皮质灰质、髓鞘化白质、未髓鞘化白质、基底神经节（BG）和脑脊液。
出生时早产的婴儿，其颅内体积平均绝对体积（269.8 mL±36.5）、全脑体积（246.5±32.3）、皮质灰质（85.53 mL±22.23）、未髓鞘化白质（142.4 mL±14.98）和髓鞘化白质（6.099 mL±1.82），与足月时早产的婴儿相比显著更低：颅内体积平均总体积（431.7±69.98）、全脑体积（391±66.1）、皮质灰质（179 mL±41.54）、未髓鞘化白质（185.3 mL±30.8）和髓鞘化白质（10.66 mL±3.05）。与足月儿相比也更低：颅内体积（427.4 mL±53.84）、全脑体积（394±49.22）、皮质灰质（181.4±29.27）、未髓鞘化白质（183.4±27.37）和髓鞘化白质（10.72±4.63）。出生时早产的婴儿，其皮质灰质相对体积（30.62±5.13）和未髓鞘化白质相对体积（53.15±4.8），与足月时早产的婴儿相比，皮质灰质相对体积（41.05±5.44）和未髓鞘化白质相对体积（43.22±5.11）有显著差异。早产儿在40周时的脑组织体积与足月儿相似。
MR分割技术表明，足月时中度早产儿和足月儿的皮质新生儿成熟情况相似。
