Yonezawa K, Matsumoto Y, Komiyama M
Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
Nucleic Acids Symp Ser. 1991(25):145-6.
Adenosine 3',5'-cyclic phosphate (cAMP) is efficiently hydrolyzed at pH 7, 50 degrees C by use of [Co-(trien) (H2O)2]3+ and [Co(tme)2-(H2O)2]3+ complexes as catalysts: trien (diethylenetriamine) and tme (1,1,2,2-tetramethylethylenediamine). The acceleration is remarkable (10(8) to 10(9) fold), decreasing half-life of cAMP from 660,000 years to 7-15 hours.
3',5'-环磷酸腺苷（cAMP）在pH值为7、50摄氏度的条件下，以[Co-(trien)(H2O)2]3+和[Co(tme)2-(H2O)2]3+配合物作为催化剂时能被高效水解：trien（二乙烯三胺）和tme（1,1,2,2-四甲基乙二胺）。这种加速作用非常显著（10的8次方至10的9次方倍），使cAMP的半衰期从66万年缩短至7 - 15小时。
