Matsumoto Y, Yonezawa K, Komiyama M
Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
Nucleic Acids Symp Ser. 1990(22):59-60.
Adenylyl (3'-5')adenosine (ApA) is effectively cleaved to two adenosine molecules by [Co(trien)(H2O)2]3+ complex (trien: triethylenetetramine). The complex (0.20 M) accelerates the cleavage by 10(5) fold, decreasing half-life of ApA from 4000 years to 9.3 days. The reaction involves general base catalysis by the hydroxide ion bound to the Co(III) ion for the formation of adenosine 2',3'-cyclic phosphate (A greater than p), followed by the prompt cleavage of the intermediate to adenosine.
腺苷酰（3'-5'）腺苷（ApA）能被[Co（三乙撑四胺）（H₂O）₂]³⁺络合物（三乙撑四胺：triethylenetetramine）有效地裂解为两个腺苷分子。该络合物（0.20 M）使裂解加速10⁵倍，将ApA的半衰期从4000年缩短至9.3天。反应涉及与Co（III）离子结合的氢氧根离子的一般碱催化作用，以形成腺苷2'，3'-环磷酸酯（A大于p），随后中间体迅速裂解为腺苷。
