抗高血压药物对勃起功能的影响：一种建议的管理算法。
The effect of antihypertensive drugs on erectile function: a proposed management algorithm.
作者信息
Doumas Michael, Douma Stella
机构信息
Department of Internal Medicine, University of Thrace, Alexandroupolis, Greece.
出版信息
J Clin Hypertens (Greenwich). 2006 May;8(5):359-64. doi: 10.1111/j.1524-6175.2005.05285.x.
The pharmacologic management of hypertension has long been implicated in the genesis of erectile dysfunction; the latter is considered the main reason of nonadherence to antihypertensive therapy. Older-generation antihypertensive drugs (central-acting, beta blockers, diuretics) negatively affect erectile function, while newer-generation agents (calcium antagonists, angiotensin-converting enzyme inhibitors) seem to have neutral effects. Preliminary data with the latest drugs (angiotensin receptor blockers) point to a beneficial effect on erectile function. Phosphodiesterase-5 inhibitors, used for the treatment of erectile dysfunction, can be safely and effectively administered to hypertensive patients (even when on multiple-agent antihypertensive therapy), with a caution regarding alpha blockers. In the case when erectile dysfunction is considered to result from antihypertensive therapy, the treating physician may either add phosphodiesterase-5 inhibitors or substitute current treatment with angiotensin receptor blockers.
长期以来，高血压的药物治疗一直被认为与勃起功能障碍的发生有关；勃起功能障碍被认为是患者不坚持抗高血压治疗的主要原因。 older-generation antihypertensive drugs (central-acting, beta blockers, diuretics) negatively affect erectile function, while newer-generation agents (calcium antagonists, angiotensin-converting enzyme inhibitors) seem to have neutral effects. Preliminary data with the latest drugs (angiotensin receptor blockers) point to a beneficial effect on erectile function. Phosphodiesterase-5 inhibitors, used for the treatment of erectile dysfunction, can be safely and effectively administered to hypertensive patients (even when on multiple-agent antihypertensive therapy), with a caution regarding alpha blockers. In the case when erectile dysfunction is considered to result from antihypertensive therapy, the treating physician may either add phosphodiesterase-5 inhibitors or substitute current treatment with angiotensin receptor blockers.
高血压的药物治疗长期以来一直被认为与勃起功能障碍的发生有关；后者被认为是不坚持抗高血压治疗的主要原因。 older-generation antihypertensive drugs (central-acting, beta blockers, diuretics) negatively affect erectile function, while newer-generation agents (calcium antagonists, angiotensin-converting enzyme inhibitors) seem to have neutral effects. Preliminary data with the latest drugs (angiotensin receptor blockers) point to a beneficial effect on erectile function. Phosphodiesterase-5 inhibitors, used for the treatment of erectile dysfunction, can be safely and effectively administered to hypertensive patients (even when on multiple-agent antihypertensive therapy), with a caution regarding alpha blockers. In the case when erectile dysfunction is considered to result from antihypertensive therapy, the treating physician may either add phosphodiesterase-5 inhibitors or substitute current treatment with angiotensin receptor blockers.
老一代抗高血压药物（中枢作用药物、β受体阻滞剂、利尿剂）对勃起功能有负面影响，而新一代药物（钙拮抗剂、血管紧张素转换酶抑制剂）似乎具有中性作用。关于最新药物（血管紧张素受体阻滞剂）的初步数据表明其对勃起功能有有益影响。用于治疗勃起功能障碍的磷酸二酯酶-5抑制剂可安全有效地用于高血压患者（即使在接受多种药物联合抗高血压治疗时），但使用α受体阻滞剂时需谨慎。如果认为勃起功能障碍是由抗高血压治疗引起的，治疗医生可以添加磷酸二酯酶-5抑制剂或用血管紧张素受体阻滞剂替代当前治疗。
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