Chittleborough Catherine R, Baldock Katherine L, Taylor Anne W, Phillips Patrick J
South Australian Department of Health, Diabetes Clearing House, Population Research and Outcome Studies Unit, PO Box 287, Rundle Mall, Adelaide, 5000, South Australia, Australia.
Qual Life Res. 2006 May;15(4):687-94. doi: 10.1007/s11136-005-3570-8.
To examine the association of health status with stage along the diabetes continuum.
DESIGN, SETTING AND PARTICIPANTS: Self-reported health status (SF-36) was assessed in the North West Adelaide Health Study, a representative population cohort (n = 4060) aged 18 years and over in metropolitan South Australia. Impaired fasting glucose (IFG), undiagnosed diabetes, diagnosed diabetes, glycaemic control and cardiovascular disease were determined from fasting blood and self-reported data.
The prevalence of diagnosed diabetes was 5.6% (95% CI: 4.9-6.3), with an additional 1.0% (95% CI: 0.7-1.4) previously undiagnosed. When compared to those with normal glucose, those with diabetes were significantly impaired on all SF-36 dimensions except Mental Health, and those with IFG (4.3%) were significantly impaired in terms of Physical Functioning and Bodily Pain when controlling for the effects of age, sex and cardiovascular disease. Poor glycaemic control (HbA1c >or= 7.0%) was also associated with impaired health status.
Health status is impaired not only among those with diagnosed diabetes but also those with IFG and undiagnosed diabetes.
研究健康状况与糖尿病连续进程各阶段之间的关联。
设计、研究地点与参与者：在阿德莱德西北健康研究中评估了自我报告的健康状况（SF-36），该研究是南澳大利亚州首府城市一个具有代表性的人群队列研究（n = 4060），研究对象为18岁及以上人群。通过空腹血液检测和自我报告数据确定空腹血糖受损（IFG）、未诊断的糖尿病、已诊断的糖尿病、血糖控制情况以及心血管疾病情况。
已诊断糖尿病的患病率为5.6%（95%可信区间：4.9 - 6.3），另有1.0%（95%可信区间：0.7 - 1.4）此前未被诊断。与血糖正常者相比，糖尿病患者在除心理健康外的所有SF-36维度上均显著受损，在控制年龄、性别和心血管疾病影响后，IFG患者（4.3%）在身体功能和身体疼痛方面也显著受损。血糖控制不佳（糖化血红蛋白≥7.0%）也与健康状况受损相关。
不仅已诊断糖尿病患者的健康状况受损，IFG患者和未诊断糖尿病患者的健康状况也受损。
