雷尼替丁对运动诱发的胃黏膜变化及出血的影响。
Effects of ranitidine for exercise induced gastric mucosal changes and bleeding.
作者信息
Choi Suck Jun, Kim Yong Sung, Chae Jeong Ryong, Cho Hong Kwan, Kim Tae Hyeon, Sohn Young Woo, Oh Yong Leol, Seo Geom Seog, Nah Yong-Ho, Choi Suck Chei
机构信息
Department of Leisure and Sports, Wonkwang Health Science College, Iksan, South Korea.
出版信息
World J Gastroenterol. 2006 Apr 28;12(16):2579-83. doi: 10.3748/wjg.v12.i16.2579.
AIM
To evaluate the effect of ranitidine on gastric mucosal changes and on GI bleeding in long distance runners.
METHODS
Twenty-four long distance runners (M: 16, F: 8, age: 18.2 +/- 1.5 years) participated in this study. A symptom questionnaire, stool hemoccult test, and upper gastrointestinal (GI) endoscopy were performed on the subjects prior to the study. The subjects took oral ranitidine (150 mg, b.i.d.) for two weeks. The upper GI endoscopy and stool Hemoccult tests were repeated after the treatment.
RESULTS
Twenty-two of the 24 runners had at least one upper GI mucosal lesion before the medication. The Endoscopic improvements were seen in eleven of the 14 cases of erosive gastritis and four of the 5 cases of esophagitis. Six subjects were Heme occult positive prior to the study, but only one was positive after the medication.
CONCLUSION
Gastric mucosal lesions and GI bleeding in long distance runners seem to be associated to acid-related factors mediated by the high level of regular running. Ranitidine seems to be and effective prophylaxis to prevent gastric mucosal lesions and GI bleeding.
目的
评估雷尼替丁对长跑运动员胃黏膜变化及胃肠道出血的影响。
方法
24名长跑运动员（男16名，女8名，年龄18.2±1.5岁）参与了本研究。在研究前对受试者进行症状问卷调查、粪便潜血试验和上消化道内镜检查。受试者口服雷尼替丁（150毫克，每日两次），持续两周。治疗后重复进行上消化道内镜检查和粪便潜血试验。
结果
24名运动员中有22名在用药前至少有一处上消化道黏膜病变。14例糜烂性胃炎中有11例内镜检查有改善，5例食管炎中有4例有改善。6名受试者在研究前潜血阳性，但用药后只有1名阳性。
结论
长跑运动员的胃黏膜病变和胃肠道出血似乎与由高水平的常规跑步介导的酸相关因素有关。雷尼替丁似乎是预防胃黏膜病变和胃肠道出血的有效药物。
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