Xie Dong, Park Jong-Gu, Faddah Mona, Zhao Jun
Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, IN 46202, USA.
J Biomater Sci Polym Ed. 2006;17(3):303-22. doi: 10.1163/156856206775997304.
A novel photo-cured amino-acid-constructed glass-ionomer cement system has been developed. Glutamic acid- and beta-alanine-based methacrylate and acrylate derivatives were synthesized, characterized and used to construct the polyalkenoic acids and formulated with water and Fuji II glass filler to form self-cured cement. Compressive strength (CS) of the cement and viscosity of the liquid were used as tools for evaluation. The effects of molar ratio and molecular weight (MW) were studied. The optimized co-polymer was further modified with glycidyl methacrylate (GM) and formulated with water, acrylic acid and Fuji II LC filler to form photo-cured cement. The effects of MW, GM tethering ratio, polymer liquid ratio and glass filler powder/polymer liquid (P/L) ratio were investigated. CS, flexural strength (FS) and viscosity were used as screening tools to find the optimal formulation. All the specimens were conditioned in distilled water at 37 degrees C for either 24 h or 7 days prior to testing. The results show that amino-acid-constructed polyalkenoic acids can be formed only from amino acid methacrylate derivatives or by co-polymerization of methacrylate with acrylate derivatives. Among the numerous co-polymers synthesized, poly(methacryloyl glutamic acid-co-acryloyl beta-alanine) or poly(MGA-co-ABA) with the molar ratio of 8:2 and MW of 19.5 kg/mol contributed the highest mechanical strengths and lower working viscosity to the cement. For photo-cured system, the effects of GM tethering ratio, polymer content and P/L ratio were significant. It is found that an appropriate ratio balance between these parameters is very important. The effect of molecular weight was not significant. The self-cured experimental cement was 32% higher in FS than Fuji II and the same in CS and DTS as Fuji II. The photo-cured experimental cement was 19%, 47% and 176% higher in CS, DTS and FS than Fuji II LC.
已开发出一种新型的光固化氨基酸构建的玻璃离子水门汀体系。合成了基于谷氨酸和β-丙氨酸的甲基丙烯酸酯和丙烯酸酯衍生物，对其进行了表征，并用于构建聚烯酸，再与水和富士II玻璃填料配制成自固化水门汀。水门汀的抗压强度（CS）和液体的粘度用作评估工具。研究了摩尔比和分子量（MW）的影响。用甲基丙烯酸缩水甘油酯（GM）对优化后的共聚物进行进一步改性，并与水、丙烯酸和富士II LC填料配制成光固化水门汀。研究了分子量、GM连接比例、聚合物液体比例和玻璃填料粉末/聚合物液体（P/L）比例的影响。使用CS、抗弯强度（FS）和粘度作为筛选工具来寻找最佳配方。在测试前，所有试样均在37℃的蒸馏水中浸泡24小时或7天。结果表明，氨基酸构建的聚烯酸只能由氨基酸甲基丙烯酸酯衍生物形成，或者通过甲基丙烯酸酯与丙烯酸酯衍生物的共聚形成。在合成的众多共聚物中，摩尔比为8:2且分子量为19.5 kg/mol的聚（甲基丙烯酰谷氨酸-co-丙烯酰β-丙氨酸）或聚（MGA-co-ABA）赋予水门汀最高的机械强度和较低的工作粘度。对于光固化体系，GM连接比例、聚合物含量和P/L比例的影响显著。发现这些参数之间适当的比例平衡非常重要。分子量的影响不显著。自固化实验水门汀的FS比富士II高32%，CS和DTS与富士II相同。光固化实验水门汀的CS、DTS和FS比富士II LC分别高19%、47%和176%。
