Xie Dong, Chung Il-Doo, Wu Wei, Lemons Jack, Puckett Aaron, Mays Jimmy
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Biomaterials. 2004 May;25(10):1825-30. doi: 10.1016/j.biomaterials.2003.08.033.
It is known that unreacted 2-hydroxyethyl methacrylate (HEMA) in current resin modified glass ionomer cements (RMGICs) shows potential cytotoxicity to pulp and surrounding tissues. Elimination of HEMA could make RMGICs more attractive for dental applications. In this research, novel six acrylate and methacrylate derivatives of amino acids were synthesized, characterized and used for replace HEMA in RMGICs. The experimental RMGICs were formulated with vinyl-containing polymer, amino acid derivative, water, and commercial Fuji II LC glass. Among all the derivatives, methacryloyl beta-alanine (MBA) was selected for further formulations due to its relatively low solution viscosity and high CS. Effects of polymer content and powder/liquid, P/L, ratio were significant. The formulation with liquid composition of 50/25/25 (polymer/MBA/water) and P/L ratio of 2.7/1 was found the optimal. It appears that this novel non-HEMA-containing RMGIC system based on amino acid derivatives will be a better dental restorative because it demonstrated improved mechanical strengths and may eliminate potential cytotoxicity in current RMGICs caused by leached HEMA. The optimal MBA-modified GIC were 20% higher in CS, 70% higher in DTS and 93% higher in FS, compared to Fuji II LC.
众所周知，目前树脂改性玻璃离子水门汀（RMGICs）中未反应的甲基丙烯酸2-羟乙酯（HEMA）对牙髓和周围组织显示出潜在的细胞毒性。消除HEMA可使RMGICs在牙科应用中更具吸引力。在本研究中，合成、表征了六种新型氨基酸丙烯酸酯和甲基丙烯酸酯衍生物，并将其用于替代RMGICs中的HEMA。实验性RMGICs由含乙烯基聚合物、氨基酸衍生物、水和市售富士II LC玻璃制成。在所有衍生物中，由于甲基丙烯酰基β-丙氨酸（MBA）的溶液粘度相对较低且转化率较高，因此被选用于进一步配方。聚合物含量和粉液比（P/L）的影响显著。发现液体组成为50/25/25（聚合物/MBA/水）且P/L比为2.7/1的配方是最佳的。基于氨基酸衍生物的这种新型不含HEMA的RMGIC系统似乎将是一种更好的牙科修复材料，因为它表现出更高的机械强度，并且可能消除当前RMGICs中由渗出的HEMA引起的潜在细胞毒性。与富士II LC相比，最佳MBA改性玻璃离子水门汀的抗压强度高20%，抗折强度高70%，抗冲强度高93%。
