Shetty Kishore
Medically Complex Patient Clinic, University of Texas Health Sciences Center, Houston, USA.
Gen Dent. 2006 Mar-Apr;54(2):140-3; quiz 144.
Periodontal disease is a common oral disease in all segments of the population, regardless of their systemic health status. The disease is generalized or localized and the severity of lesions can vary at different sites. It is possible to recognize a number of different types of periodontal disease on the basis of clinical and pathological criteria, which include the extent of periodontal destruction, the age of onset and severity of disease, the distribution of lesions, the microflora involved, and the variation in host responses. The ultimate outcome of periodontal disease in adults, whether treated or untreated, depends on patient susceptibility. While periodontopathic bacteria are recognized as the etiologic agents in periodontal disease, their interaction with and modulation of the host immune response is of fundamental importance. An interplay of protection and pathology active in periodontal disease is that of T-lymphocyte cells and the subsequent production of cytokines within the periodontal tissues.
牙周病是各年龄段人群中常见的口腔疾病，无论其全身健康状况如何。该疾病可呈广泛性或局限性，病变严重程度在不同部位可能有所不同。根据临床和病理标准，可以识别多种不同类型的牙周病，这些标准包括牙周破坏的程度、发病年龄和疾病严重程度、病变分布、所涉及的微生物群落以及宿主反应的变化。无论是否接受治疗，成人牙周病的最终结局取决于患者的易感性。虽然牙周病原菌被认为是牙周病的病因，但它们与宿主免疫反应的相互作用和调节至关重要。在牙周病中起作用的保护与病理之间的相互作用是T淋巴细胞细胞以及牙周组织内随后细胞因子的产生。
