内体分选转运复合体（ESCRT）：膜运输网络的结构与机制
The ESCRT complexes: structure and mechanism of a membrane-trafficking network.
作者信息
Hurley James H, Emr Scott D
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892-0580, USA.
出版信息
Annu Rev Biophys Biomol Struct. 2006;35:277-98. doi: 10.1146/annurev.biophys.35.040405.102126.
Abstract
The ESCRT complexes and associated proteins comprise a major pathway for the lysosomal degradation of transmembrane proteins and are critical for receptor downregulation, budding of the HIV virus, and other normal and pathological cell processes. The ESCRT system is conserved from yeast to humans. The ESCRT complexes form a network that recruits monoubiquitinated proteins and drives their internalization into lumenal vesicles within a type of endosome known as a multivesicular body. The structures and interactions of many of the components have been determined over the past three years, revealing mechanisms for membrane and cargo recruitment and for complex assembly.
摘要
内体分选转运复合体（ESCRT）及其相关蛋白构成了跨膜蛋白溶酶体降解的主要途径，对受体下调、HIV病毒出芽及其他正常和病理细胞过程至关重要。ESCRT系统在从酵母到人类的生物中保守存在。ESCRT复合体形成一个网络，招募单泛素化蛋白并驱动它们内化到一种称为多囊泡体的内体中的腔内小泡中。在过去三年中，已确定了许多组分的结构和相互作用，揭示了膜和货物招募以及复合体组装的机制。
相似文献
1
The ESCRT complexes: structure and mechanism of a membrane-trafficking network.
Annu Rev Biophys Biomol Struct. 2006;35:277-98. doi: 10.1146/annurev.biophys.35.040405.102126.
2
Protein sorting into multivesicular endosomes.
Curr Opin Cell Biol. 2003 Aug;15(4):446-55. doi: 10.1016/s0955-0674(03)00080-2.
3
Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes.
J Cell Biol. 2006 Dec 4;175(5):715-20. doi: 10.1083/jcb.200606113. Epub 2006 Nov 27.
4
Structure of the ESCRT-II endosomal trafficking complex.
Nature. 2004 Sep 9;431(7005):221-5. doi: 10.1038/nature02914. Epub 2004 Aug 25.
5
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.
Dev Cell. 2002 Aug;3(2):283-9. doi: 10.1016/s1534-5807(02)00219-8.
6
Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.
J Cell Biol. 2003 Oct 27;163(2):237-43. doi: 10.1083/jcb.200305007.
7
ESCRT proteins in physiology and disease.
Exp Cell Res. 2009 May 15;315(9):1619-26. doi: 10.1016/j.yexcr.2008.10.013. Epub 2008 Oct 28.
8
Vps27 recruits ESCRT machinery to endosomes during MVB sorting.
J Cell Biol. 2003 Aug 4;162(3):413-23. doi: 10.1083/jcb.200302136.
9
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer.
Cell. 2007 May 4;129(3):485-98. doi: 10.1016/j.cell.2007.03.016. Epub 2007 Apr 19.
10
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.
Cell. 2001 Jul 27;106(2):145-55. doi: 10.1016/s0092-8674(01)00434-2.
引用本文的文献
1
Wbm0152, an outer membrane lipoprotein of the endosymbiont of , inhibits yeast ESCRT complex activity.
bioRxiv. 2025 Jul 21:2025.07.21.665852. doi: 10.1101/2025.07.21.665852.
2
Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomes.
bioRxiv. 2025 Aug 1:2025.07.31.665751. doi: 10.1101/2025.07.31.665751.
3
DNAJC13 localization to endosomes is opposed by its J domain and its disordered C-terminus.
Mol Biol Cell. 2025 Sep 1;36(9):ar114. doi: 10.1091/mbc.E24-12-0575. Epub 2025 Jul 30.
4
Iron acquisition strategies in pathogenic fungi.
mBio. 2025 Jun 11;16(6):e0121125. doi: 10.1128/mbio.01211-25. Epub 2025 May 20.
5
Changes and application prospects of biomolecular materials in small extracellular vesicles (sEVs) after flavivirus infection.
Eur J Med Res. 2025 Apr 15;30(1):275. doi: 10.1186/s40001-025-02539-x.
6
Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment.
Korean Circ J. 2025 Mar 5. doi: 10.4070/kcj.2025.0022.
7
Any1 is a phospholipid scramblase involved in endosome biogenesis.
J Cell Biol. 2025 Apr 7;224(4). doi: 10.1083/jcb.202410013. Epub 2025 Mar 6.
8
Selective clearance of aberrant membrane proteins by TORC1-mediated micro-ER-phagy.
Cell Rep. 2025 Feb 25;44(2):115282. doi: 10.1016/j.celrep.2025.115282. Epub 2025 Feb 12.
9
Endosomal traffic disorders: a driving force behind neurodegenerative diseases.
Transl Neurodegener. 2024 Dec 24;13(1):66. doi: 10.1186/s40035-024-00460-7.
10
Clearing the JUNQ: the molecular machinery for sequestration, localization, and degradation of the JUNQ compartment.
Front Mol Biosci. 2024 Aug 21;11:1427542. doi: 10.3389/fmolb.2024.1427542. eCollection 2024.
本文引用的文献
1
Structural and mechanistic studies of VPS4 proteins.
EMBO J. 2005 Oct 19;24(20):3658-69. doi: 10.1038/sj.emboj.7600818. Epub 2005 Sep 29.
2
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A.
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13813-8. doi: 10.1073/pnas.0502165102. Epub 2005 Sep 20.
3
Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling.
EMBO J. 2005 Jul 6;24(13):2265-83. doi: 10.1038/sj.emboj.7600688. Epub 2005 Jun 9.
4
Structural basis for endosomal targeting by the Bro1 domain.
Dev Cell. 2005 Jun;8(6):937-47. doi: 10.1016/j.devcel.2005.04.001.
5
Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae.
Biochim Biophys Acta. 2005 Jul 10;1744(3):438-54. doi: 10.1016/j.bbamcr.2005.04.004.
6
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain.
J Biol Chem. 2005 May 20;280(20):19600-6. doi: 10.1074/jbc.M501510200. Epub 2005 Mar 7.
7
The Hrs/STAM complex in the downregulation of receptor tyrosine kinases.
J Biochem. 2005 Jan;137(1):1-8. doi: 10.1093/jb/mvi001.
8
Signaling through monoubiquitination.
Curr Top Microbiol Immunol. 2004;286:149-85. doi: 10.1007/978-3-540-69494-6_6.
9
The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.
J Biol Chem. 2005 Mar 18;280(11):10548-55. doi: 10.1074/jbc.M413734200. Epub 2005 Jan 11.
10
Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.
J Biol Chem. 2005 Apr 1;280(13):12799-809. doi: 10.1074/jbc.M413968200. Epub 2005 Jan 4.
Zotero 插件