Dong Jianru, Tong Weiwei, Liu Mingyan, Liu Mengyu, Liu Jinyue, Jin Xin, Chen Ju, Jia Huachao, Gao Menglin, Wei Minjie, Duan Ying, Zhong Xin
School of Pharmacy, China Medical University, Shenyang, 110122, China.
Weifang Hospital of Traditional Chinese Medicine, Weifang, 261000, China.
Transl Neurodegener. 2024 Dec 24;13(1):66. doi: 10.1186/s40035-024-00460-7.
Endosomes are crucial sites for intracellular material sorting and transportation. Endosomal transport is a critical process involved in the selective uptake, processing, and intracellular transport of substances. The equilibrium between endocytosis and circulation mediated by the endosome-centered transport pathway plays a significant role in cell homeostasis, signal transduction, and immune response. In recent years, there have been hints linking endosomal transport abnormalities to neurodegenerative diseases, including Alzheimer's disease. Nonetheless, the related mechanisms remain unclear. Here, we provide an overview of endosomal-centered transport pathways and highlight potential physiological processes regulated by these pathways, with a particular focus on the correlation of endosomal trafficking disorders with common pathological features of neurodegenerative diseases. Additionally, we summarize potential therapeutic agents targeting endosomal trafficking for the treatment of neurodegenerative diseases.
内涵体是细胞内物质分选和运输的关键场所。内涵体运输是一个关键过程，涉及物质的选择性摄取、加工和细胞内运输。以内涵体为中心的运输途径介导的内吞作用和循环之间的平衡在细胞稳态、信号转导和免疫反应中起着重要作用。近年来，有迹象表明内涵体运输异常与神经退行性疾病（包括阿尔茨海默病）有关。然而，相关机制仍不清楚。在此，我们概述了以内涵体为中心的运输途径，并强调了这些途径调节的潜在生理过程，特别关注内涵体运输障碍与神经退行性疾病常见病理特征的相关性。此外，我们总结了针对内涵体运输的潜在治疗药物，用于治疗神经退行性疾病。
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