黄病毒感染后生物分子材料在小细胞外囊泡（sEVs）中的变化及应用前景

Changes and application prospects of biomolecular materials in small extracellular vesicles (sEVs) after flavivirus infection.

作者信息

Du Gengting, He Junhua, Zhan Yan, Chen Leru, Hu Yue, Qian Jiaojiao, Huang Huan, Meng Fanjin, Shan Laiyou, Chen Zhiyu, Hu Dan, Zhu Changqiang, Yue Ming, Qi Yong, Tan Weilong

机构信息

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, People's Republic of China.

Nanjing Bioengineering (Gene) Technology Center for Medicines, Nanjing, People's Republic of China.

出版信息

Eur J Med Res. 2025 Apr 15;30(1):275. doi: 10.1186/s40001-025-02539-x.

DOI:10.1186/s40001-025-02539-x

PMID:40229861

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11998145/

Abstract

Small extracellular vesicles (sEVs), also known as exosomes, are membranous vesicles filled with various proteins and nucleic acids, serving as a communication vector between cells. Recent research has highlighted their role in viral diseases. This review synthesizes current understanding of viral sEVs and includes recent findings on sEVs infected with flaviviruses. It discusses the implications of viral sEVs research for advancing arbovirus sEVs research and anticipates the potential applications of sEVs in flavivirus infections.

摘要

小细胞外囊泡（sEVs），也被称为外泌体，是充满各种蛋白质和核酸的膜性囊泡，充当细胞间的通讯载体。最近的研究突出了它们在病毒性疾病中的作用。这篇综述综合了目前对病毒sEVs的认识，并纳入了感染黄病毒的sEVs的最新研究结果。它讨论了病毒sEVs研究对推进虫媒病毒sEVs研究的意义，并展望了sEVs在黄病毒感染中的潜在应用。