Duncko Roman, Makatsori Aikaterini, Fickova Emilia, Selko Dusan, Jezova Daniela
Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1058-66. doi: 10.1016/j.pnpbp.2006.04.002. Epub 2006 May 9.
Contradicting data are available on stress responsiveness in subjects with high anxiety. In the present study we tested the hypothesis that high trait anxiety is associated with impaired coordination of the stress response, rather than global hypo- or hyper-responsiveness. The sample consisted of subjects with high (n=15) and with low (n=12) trait anxiety. Subjects with middle-range levels of anxiety were excluded from the study. After psychological characterization, the volunteers were exposed to a public speech procedure. A spectrum of neuroendocrine parameters was measured before, during and after the procedure and the results were analyzed by exploratory statistics. Psychological characterization of subjects revealed a lower preference for task-oriented but a higher one for emotion-oriented coping strategies as well as lower scores on hardiness in subjects with high trait anxiety. After the speech procedure, differences in selected mood and personality characteristics were observed, with the anxious group scoring significantly higher in scales for stress, tiredness, arousal, anxiety and depression. Factor analysis revealed that one common factor grouped blood pressure, catecholamine concentrations in blood and heart rate in non-anxious subjects, while three distinct factors separated these parameters in anxious subjects. Correlation analysis in anxious subjects showed that lower adrenocorticotropin (ACTH) and cortisol responses during stress were associated with exaggerated perception of stress and worse mental performance. Our findings indicate that subjects with high anxiety have different relationships between specific neuroendocrine parameters, subjective perception of stress and Stroop test performance.
关于高焦虑个体的应激反应性，存在相互矛盾的数据。在本研究中，我们检验了这样一个假设：高特质焦虑与应激反应的协调性受损有关，而非整体反应低下或亢进。样本包括高特质焦虑组（n = 15）和低特质焦虑组（n = 12）的受试者。研究排除了中等焦虑水平的受试者。在进行心理特征描述后，让志愿者们经历一场公开演讲程序。在该程序进行前、进行期间和进行后，测量了一系列神经内分泌参数，并通过探索性统计分析结果。对受试者的心理特征描述显示，高特质焦虑的受试者对任务导向型应对策略的偏好较低，而对情绪导向型应对策略的偏好较高，同时在心理韧性得分上也较低。演讲程序后，观察到了所选情绪和人格特征方面的差异，焦虑组在压力、疲劳、唤醒、焦虑和抑郁量表上的得分显著更高。因子分析表明，一个共同因子将非焦虑受试者的血压、血液中儿茶酚胺浓度和心率归为一组，而在焦虑受试者中，这三个参数由三个不同的因子区分开来。对焦虑受试者的相关分析表明，应激期间较低的促肾上腺皮质激素（ACTH）和皮质醇反应与对应激的过度感知以及较差的心理表现有关。我们的研究结果表明，高焦虑受试者在特定神经内分泌参数、主观应激感知和 Stroop 测试表现之间存在不同的关系。
