Schelz Zsuzsanna, Molnar Joseph, Hohmann Judit
Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged H-6720, Szeged, Dóm tér 10, Hungary.
Fitoterapia. 2006 Jun;77(4):279-85. doi: 10.1016/j.fitote.2006.03.013. Epub 2006 May 11.
The antimicrobial and antiplasmid activities of essential oils (orange oil, eucalyptus oil, fennel oil, geranium oil, juniper oil, peppermint oil, rosemary oil, purified turpentine oil, thyme oil, Australian tea tree oil) and of menthol, the main component of peppermint oil, were investigated. The antimicrobial activities were determined on the Gram (+) Staphylococcus epidermidis and the Gram (-) Escherichia coli F'lac K12 LE140, and on two yeast Saccharomyces cerevisiae 0425 delta/1 and 0425 52C strains. The antiplasmid activities were investigated on E. coli F'lac bacterial strain. Each of the oils exhibited antimicrobial activity and three of them antiplasmid action. The interaction of peppermint oil and menthol with the antibiotics was studied on the same bacterial strain with the checkerboard method. Peppermint oil and menthol displayed additive synergy with oxytetracycline. A new mechanism of plasmid curing was established for one of the oil components.
研究了香精油（橙油、桉叶油、茴芹油、天竺葵油、杜松油、薄荷油、迷迭香油、精制松节油、百里香油、澳洲茶树油）以及薄荷油的主要成分薄荷醇的抗菌和抗质粒活性。对革兰氏阳性的表皮葡萄球菌、革兰氏阴性的大肠杆菌F'lac K12 LE140以及两种酵母酿酒酵母0425 delta/1和0425 52C菌株测定了抗菌活性。在大肠杆菌F'lac菌株上研究了抗质粒活性。每种油均表现出抗菌活性，其中三种具有抗质粒作用。采用棋盘法在同一菌株上研究了薄荷油和薄荷醇与抗生素的相互作用。薄荷油和薄荷醇与土霉素表现出相加协同作用。为其中一种油成分建立了一种新的质粒消除机制。
