Paraskevas K I, Liapis C D, Hamilton G, Mikhailidis D P
Department of Vascular Surgery, Athens University Medical School, Athens, Greece.
Eur J Vasc Endovasc Surg. 2006 Sep;32(3):286-93. doi: 10.1016/j.ejvs.2006.03.009. Epub 2006 May 11.
To determine whether statins can reduce perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery.
A search using Pubmed was performed to identify reports in English. The search terms were: "statins", "perioperative morbidity", "perioperative mortality" and "vascular surgery". We excluded studies dealing with the effect of statins in cardiac surgery. Retrieved articles were manually searched.
Current evidence shows that statins decrease perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery. Any benefit probably occurs soon (within a month) after initiating treatment.
Appropriately designed trials need to confirm the beneficial effect of perioperative statin therapy in various patient categories. The optimal duration and dose of perioperative statin therapy should be defined.
确定他汀类药物是否能降低接受非心脏血管手术患者的围手术期发病率和死亡率。
使用PubMed进行检索以识别英文报告。检索词为：“他汀类药物”、“围手术期发病率”、“围手术期死亡率”和“血管手术”。我们排除了关于他汀类药物在心脏手术中作用的研究。对检索到的文章进行人工检索。
目前的证据表明，他汀类药物可降低接受非心脏血管手术患者的围手术期发病率和死亡率。任何益处可能在开始治疗后不久（一个月内）出现。
需要进行适当设计的试验来证实围手术期他汀类药物治疗对不同患者类别的有益效果。应确定围手术期他汀类药物治疗的最佳持续时间和剂量。
